Journal article
Seizure and myelin oligodendrocyte glycoprotein antibody-associated encephalomyelitis in a retrospective cohort of Chinese patients
Frontiers in Neurology, Vol.10
2019
Abstract
Background: Myelin oligodendrocyte glycoprotein (MOG) antibody associated encephalomyelitis is increasingly being considered a distinct disease entity, with seizures and encephalopathy commonly reported. We investigated the clinical features of MOG-IgG positive patients presenting with seizures and/or encephalopathy in a single cohort.
Methods: Consecutive patients with suspected idiopathic inflammatory demyelinating diseases were recruited from a tertiary University hospital in Guangdong province, China. Subjects with MOG-IgG seropositivity were analyzed according to whether they presented with or without seizure and/or encephalopathy.
Results: Overall, 58 subjects seropositive for MOG-IgG were analyzed, including 23 (40%) subjects presenting with seizures and/or encephalopathy. Meningeal irritation (P = 0.030), fever (P = 0.001), headache (P = 0.001), nausea, and vomiting (P = 0.004) were more commonly found in subjects who had seizures and/or encephalopathy, either at presentation or during the disease course. Nonetheless, there was less optic nerve (4/23, 17.4%, P = 0.003) and spinal cord (6/16, 37.5%, P = 0.037) involvement as compared to subjects without seizures or encephalopathy. Most MOG encephalomyelitis subjects had cortical/subcortical lesions: 65.2% (15/23) in the seizures and/or encephalopathy group and 50.0% (13/26) in the without seizures or encephalopathy group. Cerebrospinal fluid (CSF) leukocytes were elevated in both groups. Subgroup analysis showed that 30% (7/23) MOG-IgG positive subjects with seizures and/or encephalopathy had been misdiagnosed for central nervous system infection on the basis of meningoencephalitis symptoms and elevated CSF leukocytes (P = 0.002).
Conclusions: Seizures and encephalopathy are not rare in MOG encephalomyelitis, and are commonly associated with cortical and subcortical brain lesions. MOG-encephalomyelitis often presents with clinical meningoencephalitis symptoms and abnormal CSF findings mimicking central nervous system infection in pediatric and young adult patients.
Details
- Title
- Seizure and myelin oligodendrocyte glycoprotein antibody-associated encephalomyelitis in a retrospective cohort of Chinese patients
- Authors/Creators
- X. Zhong (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen UniversityY. Zhou (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen UniversityY. Chang (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen UniversityJ. Wang (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen UniversityY. Shu (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen UniversityX. Sun (Author/Creator)L. Peng (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen UniversityA.Y. Lau (Author/Creator) - Chinese University of Hong KongA.G. Kermode (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen UniversityW. Qiu (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen University
- Publication Details
- Frontiers in Neurology, Vol.10
- Publisher
- Frontiers Media
- Identifiers
- 991005543918507891
- Copyright
- © 2019 The Author(s)
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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