Journal article
Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans
Science, Vol.370(6512), pp.89-94
2020
Abstract
Many unknowns exist about human immune responses to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. SARS-CoV-2–reactive CD4+ T cells have been reported in unexposed individuals, suggesting preexisting cross-reactive T cell memory in 20 to 50% of people. However, the source of those T cells has been speculative. Using human blood samples derived before the SARS-CoV-2 virus was discovered in 2019, we mapped 142 T cell epitopes across the SARS-CoV-2 genome to facilitate precise interrogation of the SARS-CoV-2–specific CD4+ T cell repertoire. We demonstrate a range of preexisting memory CD4+ T cells that are cross-reactive with comparable affinity to SARS-CoV-2 and the common cold coronaviruses human coronavirus (HCoV)-OC43, HCoV-229E, HCoV-NL63, and HCoV-HKU1. Thus, variegated T cell memory to coronaviruses that cause the common cold may underlie at least some of the extensive heterogeneity observed in coronavirus disease 2019 (COVID-19) disease.
Details
- Title
- Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans
- Authors/Creators
- J. Mateus (Author/Creator)A. Grifoni (Author/Creator)A. Tarke (Author/Creator)J. Sidney (Author/Creator)S.I. Ramirez (Author/Creator)J.M. Dan (Author/Creator)Z.C. Burger (Author/Creator)S.A. Rawlings (Author/Creator)D.M. Smith (Author/Creator)E. Phillips (Author/Creator)S. Mallal (Author/Creator)M. Lammers (Author/Creator)P. Rubiro (Author/Creator)L. Quiambao (Author/Creator)A. Sutherland (Author/Creator)E.D. Yu (Author/Creator)R. da Silva Antunes (Author/Creator)J. Greenbaum (Author/Creator)A. Frazier (Author/Creator)A.J. Markmann (Author/Creator)L. Premkumar (Author/Creator)A. de Silva (Author/Creator)B. Peters (Author/Creator)S. Crotty (Author/Creator)A. Sette (Author/Creator)D. Weiskopf (Author/Creator)
- Publication Details
- Science, Vol.370(6512), pp.89-94
- Publisher
- American Association for the Advancement of Science
- Identifiers
- 991005543953007891
- Copyright
- © 2020 American Association for the Advancement of Science.
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
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- Citation topics
- 1 Clinical & Life Sciences
- 1.104 Virology - General
- 1.104.1353 Coronavirus Research
- Web Of Science research areas
- Immunology
- ESI research areas
- Immunology