Journal article
Selenomethylene locked nucleic acid enables reversible hybridization in response to redox changes
Angewandte Chemie: International Edition, Vol.52(19), pp.5074-5078
2013
Abstract
Locking up selenium: A new conformationally restricted nucleic acid with a 2′,4′-selenomethylene bridge (SeLNA) can be reversibly converted into its oxidized form (SeOLNA), and the hybridization of a modified oligonucleotide was shown to be dependent on the oxidation state. A SeLNA-modified molecular-beacon-type probe (see scheme; F=fluorophore, Q=quencher) can be used as a sensor for changes in the redox environment.
Details
- Title
- Selenomethylene locked nucleic acid enables reversible hybridization in response to redox changes
- Authors/Creators
- K. Morihiro (Author/Creator) - The University of OsakaT. Kodama (Author/Creator) - Nagoya University. Kentefu (Author/Creator)Y. Moai (Author/Creator) - Nagoya UniversityR.N. Veedu (Author/Creator) - The University of QueenslandS. Obika (Author/Creator) - The University of Osaka
- Publication Details
- Angewandte Chemie: International Edition, Vol.52(19), pp.5074-5078
- Publisher
- Wiley
- Identifiers
- 991005540022607891
- Copyright
- © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 2 Chemistry
- 2.170 Nucleic Acids Chemistry
- 2.170.988 Oligonucleotide Modifications
- Web Of Science research areas
- Chemistry, Multidisciplinary
- ESI research areas
- Chemistry