Self-reported physical activity is associated with Tau Burden measured by Positron Emission Tomography

B.M. Brown; S.R. Rainey-Smith; V. Dore; J.J. Peiffer; S.C. Burnham; S.M. Laws; K. Taddei; D. Ames; C.L. Masters; C.C. Rowe; R.N. Martins; V.L. Villemagne; M. Cristina Polidori

doi:10.3233/JAD-170998

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Self-reported physical activity is associated with Tau Burden measured by Positron Emission Tomography

Journal article

Peer reviewed

Self-reported physical activity is associated with Tau Burden measured by Positron Emission Tomography

B.M. Brown, S.R. Rainey-Smith, V. Dore, J.J. Peiffer, S.C. Burnham, S.M. Laws, K. Taddei, D. Ames, C.L. Masters, C.C. Rowe, …

Journal of Alzheimer's disease : JAD, Vol.63(4), pp.1299-1305

2018

DOI: https://doi.org/10.3233/JAD-170998

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Abstract

Numerous animal studies have reported exercise reduces the accumulation of Alzheimer’s disease pathology, including amyloid-β (Aβ) and tau. Furthermore, we previously reported a relationship between higher levels of physical activity (PA) and lower brain Aβ burden in a human population. The recent advent of tau positron emission tomography (PET) tracers enables us to extend our investigations into the evaluation of the relationship between PA and brain tau burden. Utilizing data from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study, we have examined the cross-sectional relationship between habitual PA and PET-quantified tau burden. Forty-three cognitively healthy older adults were categorized into low-moderate PA (LMPA; n = 16) or high PA (HPA; n = 27), based on self-reported PA levels. Tau PET imaging with the AV1451 tracer was conducted on all participants. The LMPA group had significantly higher neocortical tau burden (presented as a z-score; 1.22±1.98), compared to the HPA group (z-score: – 0.28±1.18). The difference between the LMPA and HPA groups was also evident when examining regional tau burden in the temporoparietal cortex and the prefrontal cortex. Our results suggest an association between self-reported PA level and brain tau burden. Future longitudinal and interventional studies utilizing larger samples sizes are vital to further investigate the nature of the relationship between tau and PA.

Details

Title: Self-reported physical activity is associated with Tau Burden measured by Positron Emission Tomography
Authors/Creators: B.M. Brown (Author/Creator) - Murdoch University
S.R. Rainey-Smith (Author/Creator)
V. Dore (Author/Creator) - CSIRO Health and Biosecurity
J.J. Peiffer (Author/Creator) - Murdoch University
S.C. Burnham (Author/Creator) - CSIRO Health and Biosecurity
S.M. Laws (Author/Creator) - Edith Cowan University
K. Taddei (Author/Creator) - Edith Cowan University
D. Ames (Author/Creator) - The University of Melbourne
C.L. Masters (Author/Creator) - Florey Institute of Neuroscience and Mental Health
C.C. Rowe (Author/Creator) - Austin Health
R.N. Martins (Author/Creator) - Edith Cowan University
V.L. Villemagne (Author/Creator) - Austin Health
M. Cristina Polidori (Author/Creator)
Publication Details: Journal of Alzheimer's disease : JAD, Vol.63(4), pp.1299-1305
Publisher: IOS Press
Identifiers: 991005544001707891
Murdoch Affiliation: School of Psychology and Exercise Science
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.52 Neurodegenerative Diseases; 1.52.60 Dementia
Web Of Science research areas: Neurosciences
ESI research areas: Neuroscience & Behavior