Sequence analysis of HLA-Bw53, a common West African allele, suggests an origin by gene conversion of HLA-B35

C.E.M. Allsopp; A.V.S. Hill; D. Kwiatkowski; A. Hughes; M. Bunce; C.J. Taylor; L. Pazmany; D. Brewster; A.J. McMichael; B.M. Greenwood

doi:10.1016/0198-8859(91)90078-N

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Sequence analysis of HLA-Bw53, a common West African allele, suggests an origin by gene conversion of HLA-B35

Journal article

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Sequence analysis of HLA-Bw53, a common West African allele, suggests an origin by gene conversion of HLA-B35

C.E.M. Allsopp, A.V.S. Hill, D. Kwiatkowski, A. Hughes, M. Bunce, C.J. Taylor, L. Pazmany, D. Brewster, A.J. McMichael and B.M. Greenwood

Human Immunology, Vol.30(2), pp.105-109

1991

DOI: https://doi.org/10.1016/0198-8859(91)90078-N

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Abstract

In the West African population of the Gambia the class I antigen HLA-Bw53 is found at high frequency. We used the polymerase chain reaction to amplify cDNA from an individual homozygous for this allele and determined the nucleotide sequence of the polymorphic α1 and α2 domains. The HLA-Bw53 sequence is identical to HLA-B35 except for a short sequence at the 3′ end of exon 2 (encoding the α1 domain) which specifies a Bw4 rather than a Bw6 motif. This suggests an origin for HLA-Bw53 involving a gene conversion of HLA-B35 by an allele containing this Bw4 sequence. The α2 domain shared by HLA-Bw53, -B35, and -Bw58 is particularly common in sub-Saharan Africans.

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Title: Sequence analysis of HLA-Bw53, a common West African allele, suggests an origin by gene conversion of HLA-B35
Authors/Creators: C.E.M. Allsopp (Author/Creator) - John Radcliffe Hospital
A.V.S. Hill (Author/Creator) - Moleculgr Immunology Group, Institute of Molecular Medicine, UK
D. Kwiatkowski (Author/Creator) - John Radcliffe Hospital
A. Hughes (Author/Creator) - Royal Victoria Hospital, Banjul, The Gamiba,West Central African Republic
M. Bunce (Author/Creator) - Nuffield Department of Surgery, UK
C.J. Taylor (Author/Creator) - Nuffield Department of Surgery, UK
L. Pazmany (Author/Creator) - Moleculgr Immunology Group, Institute of Molecular Medicine, UK
D. Brewster (Author/Creator) - Royal Victoria Hospital, Banjul, The Gamiba,West Central African Republic
A.J. McMichael (Author/Creator) - Moleculgr Immunology Group, Institute of Molecular Medicine, UK
B.M. Greenwood (Author/Creator) - John Radcliffe Hospital
Publication Details: Human Immunology, Vol.30(2), pp.105-109
Publisher: Elsevier BV
Identifiers: 991005540920607891
Copyright: 1991 Elsevier Inc.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.6 Immunology; 1.6.607 MHC Diversity
Web Of Science research areas: Immunology
ESI research areas: Immunology