Journal article
Sequence and polymorphism analysis of the murine gene encoding histidyl-tRNA synthetase
Gene, Vol.178(1-2), pp.151-156
1996
Abstract
The murine histidyl-tRNA synthetase-encoding gene (MMHRS) coding region has been cloned and sequenced. The 1527-bp transcript shows a strikingly similar structural organization to that of its human counterpart, particularly within the three class II aminoacyl-tRNA synthetase structural motifs and the two histidyl-tRNA synthetase signature regions. It is predicted, as in humans, to have a coiled-coil alpha-helical structure that is characteristic of many autoantigens. MMHRS shows some degree of polymorphism at both the DNA and amino-acid levels, although its sequence is well conserved amongst the commonly used laboratory mouse strains.
Details
- Title
- Sequence and polymorphism analysis of the murine gene encoding histidyl-tRNA synthetase
- Authors/Creators
- L.M. Blechynden (Author/Creator) - Queen Elizabeth II Medical CentreC.M. Lawson (Author/Creator) - Queen Elizabeth II Medical CentreM.J. Garlepp (Author/Creator) - Queen Elizabeth II Medical Centre
- Publication Details
- Gene, Vol.178(1-2), pp.151-156
- Publisher
- Elsevier BV
- Identifiers
- 991005540553507891
- Copyright
- © 1996 Published by Elsevier B.V.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 2 Chemistry
- 2.170 Nucleic Acids Chemistry
- 2.170.185 RNA Translation Dynamics
- Web Of Science research areas
- Genetics & Heredity
- ESI research areas
- Molecular Biology & Genetics