Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 714 adults from Colombo, Sri Lanka

A. Grifoni; D. Weiskopf; C.S. Lindestam Arlehamn; M. Angelo; S. Leary; J. Sidney; A. Frazier; E. Phillips; S. Mallal; S.J. Mack; R. Tippalagama; S. Goonewardana; S. Premawansa; G. Premawansa; A. Wijewickrama; A.D. De Silva; A. Sette

doi:10.1016/j.humimm.2017.12.007

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Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 714 adults from Colombo, Sri Lanka

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Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 714 adults from Colombo, Sri Lanka

A. Grifoni, D. Weiskopf, C.S. Lindestam Arlehamn, M. Angelo, S. Leary, J. Sidney, A. Frazier, E. Phillips, S. Mallal, S.J. Mack, …

Human Immunology, Vol.79(2), pp.87-88

2017

DOI: https://doi.org/10.1016/j.humimm.2017.12.007

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Abstract

DNA sequence-based typing at the HLA-A, -B, -C, -DPB1, -DQA1, -DQB1, and -DRB1 loci was performed on 714 healthy adult blood bank donors from Colombo, Sri Lanka, to characterize allele frequencies in support of studies on T cell immunity against pathogens, including Dengue virus. Deviations from Hardy Weinberg proportions were not detected at any locus. Several alleles were found in >30% of individuals, including the class II alleles DPB1 * 04:01, DPB1 * 02:01, DQB1 * 06:01 and DRB1 * 07:01, and the class I alleles A * 33:03 and A * 24:02. Genotype data will be available in the Allele Frequencies Net Database.

Details

Title: Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 714 adults from Colombo, Sri Lanka
Authors/Creators: A. Grifoni (Author/Creator)
D. Weiskopf (Author/Creator)
C.S. Lindestam Arlehamn (Author/Creator)
M. Angelo (Author/Creator)
S. Leary (Author/Creator)
J. Sidney (Author/Creator)
A. Frazier (Author/Creator)
E. Phillips (Author/Creator)
S. Mallal (Author/Creator)
S.J. Mack (Author/Creator)
R. Tippalagama (Author/Creator)
S. Goonewardana (Author/Creator)
S. Premawansa (Author/Creator)
G. Premawansa (Author/Creator)
A. Wijewickrama (Author/Creator)
A.D. De Silva (Author/Creator)
A. Sette (Author/Creator)
Publication Details: Human Immunology, Vol.79(2), pp.87-88
Publisher: Elsevier BV
Identifiers: 991005540514107891
Copyright: © 2018 American Society for Histocompatibility and Immunogenetics.
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.6 Immunology; 1.6.607 MHC Diversity
Web Of Science research areas: Immunology
ESI research areas: Immunology