Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 339 adults from Managua, Nicaragua

D. Weiskopf; A. Grifoni; C.S.L. Arlehamn; M. Angelo; S. Leary; J. Sidney; A. Frazier; S.J. Mack; E. Phillips; S. Mallal; C. Cerpas; A. Balmaseda; E. Harris; A. Sette

doi:10.1016/j.humimm.2017.11.002

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Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 339 adults from Managua, Nicaragua

Journal article

Peer reviewed

Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 339 adults from Managua, Nicaragua

D. Weiskopf, A. Grifoni, C.S.L. Arlehamn, M. Angelo, S. Leary, J. Sidney, A. Frazier, S.J. Mack, E. Phillips, S. Mallal, …

Human Immunology, Vol.79(1), pp.1-2

2018

DOI: https://doi.org/10.1016/j.humimm.2017.11.002

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Abstract

DNA sequence-based typing at the HLA-A, -B, -C, -DPB1, -DQA1, -DQB1, and -DRB1 loci was performed on anonymized samples provided by 339 healthy adult blood bank donors in Managua, Nicaragua. The purpose of the study was to characterize allele frequencies in the local population to support studies of T cell immunity against pathogens, including Dengue virus. Deviations from Hardy Weinberg proportions were detected for all class II loci (HLA-DPB1, -DQA1, -DQB1 and -DRB1), and at the class I C locus, but not at the class I A and B loci. The genotype data will be available in the Allele Frequencies Net Database.

Details

Title: Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 339 adults from Managua, Nicaragua
Authors/Creators: D. Weiskopf (Author/Creator) - La Jolla Institute for Immunology
A. Grifoni (Author/Creator) - La Jolla Institute for Immunology
C.S.L. Arlehamn (Author/Creator) - La Jolla Institute for Immunology
M. Angelo (Author/Creator) - La Jolla Institute for Immunology
S. Leary (Author/Creator) - Murdoch University
J. Sidney (Author/Creator) - La Jolla Institute for Immunology
A. Frazier (Author/Creator) - La Jolla Institute for Immunology
S.J. Mack (Author/Creator)
E. Phillips (Author/Creator) - Murdoch University
S. Mallal (Author/Creator) - Murdoch University
C. Cerpas (Author/Creator) - Ministerio de Salud
A. Balmaseda (Author/Creator) - Ministerio de Salud
E. Harris (Author/Creator) - University of California, Berkeley
A. Sette (Author/Creator) - University of California San Diego
Publication Details: Human Immunology, Vol.79(1), pp.1-2
Publisher: Elsevier BV
Identifiers: 991005540824507891
Copyright: © 2017 American Society for Histocompatibility and Immunogenetics
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.6 Immunology; 1.6.607 MHC Diversity
Web Of Science research areas: Immunology
ESI research areas: Immunology