Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 496 adults from San Diego, California, USA

E. Moore; A. Grifoni; D. Weiskopf; V. Schulten; C.S.L. Arlehamn; M. Angelo; J. Pham; S. Leary; J. Sidney; D. Broide; A. Frazier; E. Phillips; S. Mallal; S.J. Mack; A. Sette

doi:10.1016/j.humimm.2018.09.008

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Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 496 adults from San Diego, California, USA

Journal article

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Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 496 adults from San Diego, California, USA

E. Moore, A. Grifoni, D. Weiskopf, V. Schulten, C.S.L. Arlehamn, M. Angelo, J. Pham, S. Leary, J. Sidney, D. Broide, …

Human Immunology, Vol.79(12), pp.821-822

2018

DOI: https://doi.org/10.1016/j.humimm.2018.09.008

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Abstract

DNA sequence-based typing at the HLA-A, -B, -C, -DPB1, -DQA1, -DQB1, and -DRB1 loci was performed on 496 healthy adult donors from San Diego, California, to characterize allele frequencies in support of studies of T cell responses to common allergens. Deviations from Hardy Weinberg proportions were detected at each locus except A and C. Several alleles were found in more than 15% of individuals, including the class II alleles DPB1∗02:01, DPB1∗04:01, DQA1∗01:02, DQA1∗05:01, DQB1∗03:01, and the class I allele A∗02:01. Genotype data will be available in the Allele Frequencies Net Database (AFND 3562).

Details

Title: Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 496 adults from San Diego, California, USA
Authors/Creators: E. Moore (Author/Creator)
A. Grifoni (Author/Creator)
D. Weiskopf (Author/Creator)
V. Schulten (Author/Creator)
C.S.L. Arlehamn (Author/Creator)
M. Angelo (Author/Creator)
J. Pham (Author/Creator)
S. Leary (Author/Creator)
J. Sidney (Author/Creator)
D. Broide (Author/Creator)
A. Frazier (Author/Creator)
E. Phillips (Author/Creator)
S. Mallal (Author/Creator)
S.J. Mack (Author/Creator)
A. Sette (Author/Creator)
Publication Details: Human Immunology, Vol.79(12), pp.821-822
Publisher: Elsevier BV
Identifiers: 991005544287007891
Copyright: © 2018 Published by Elsevier Inc. on behalf of American Society for Histocompatibility and Immunogenetics.
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.6 Immunology; 1.6.607 MHC Diversity
Web Of Science research areas: Immunology
ESI research areas: Immunology