Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 159 individuals from the Worcester region of the Western Cape province of South Africa

A. Grifoni; J. Sidney; C. Carpenter; E. Phillips; S. Mallal; T.J. Scriba; A. Sette; C.S. Lindestam Arlehamn

doi:10.1016/j.humimm.2018.01.004

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Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 159 individuals from the Worcester region of the Western Cape province of South Africa

Journal article

Peer reviewed

Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 159 individuals from the Worcester region of the Western Cape province of South Africa

A. Grifoni, J. Sidney, C. Carpenter, E. Phillips, S. Mallal, T.J. Scriba, A. Sette and C.S. Lindestam Arlehamn

Human Immunology, Vol.79(3), pp.143-144

2018

DOI: https://doi.org/10.1016/j.humimm.2018.01.004

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Abstract

DNA sequence-based typing at the HLA-A, -B, -C, -DPA1, -DPB1, -DQA1, -DQB1, -DRB1, and -DRB3/4/5 loci was performed on samples provided by 159 individuals from the Worcester region of the Western Cape province of South Africa. The purpose of the study was to characterize allele frequencies in the local population, to support studies of T cell immunity against pathogens, including Mycobacterium tuberculosis. There are no detectable deviations from Hardy Weinberg proportions for the HLA-A, -B, -C, -DPA1, -DPB1, -DQA1, and -DRB1 loci. A minor deviation was detected at the HLA-DQB1 locus due to an excess of homozygotes. The genotype data are available in the Allele Frequencies Net Database under identifier 3425.

Details

Title: Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 159 individuals from the Worcester region of the Western Cape province of South Africa
Authors/Creators: A. Grifoni (Author/Creator) - La Jolla Institute for Immunology
J. Sidney (Author/Creator) - La Jolla Institute for Immunology
C. Carpenter (Author/Creator) - La Jolla Institute for Immunology
E. Phillips (Author/Creator) - Vanderbilt University
S. Mallal (Author/Creator) - Vanderbilt University
T.J. Scriba (Author/Creator) - South African Tuberculosis Vaccine Initiative
A. Sette (Author/Creator) - La Jolla Institute for Immunology
C.S. Lindestam Arlehamn (Author/Creator)
Publication Details: Human Immunology, Vol.79(3), pp.143-144
Publisher: Elsevier BV
Identifiers: 991005544315607891
Copyright: © 2018 Published by Elsevier Inc. on behalf of American Society for Histocompatibility and Immunogenetics
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.6 Immunology; 1.6.607 MHC Diversity
Web Of Science research areas: Immunology
ESI research areas: Immunology