Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 100 Luo infants from the Boro area of Nyanza Province, Kenya

C.S.L. Arlehamn; R. Copin; S. Leary; S.J. Mack; E. Phillips; S. Mallal; A. Sette; G. Blatner; H. Siefers; J.D. Ernst

doi:10.1016/j.humimm.2017.03.007

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Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 100 Luo infants from the Boro area of Nyanza Province, Kenya

Journal article

Peer reviewed

Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 100 Luo infants from the Boro area of Nyanza Province, Kenya

C.S.L. Arlehamn, R. Copin, S. Leary, S.J. Mack, E. Phillips, S. Mallal, A. Sette, G. Blatner, H. Siefers and J.D. Ernst

Human Immunology, Vol.78(4), pp.325-326

2017

DOI: https://doi.org/10.1016/j.humimm.2017.03.007

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Abstract

One hundred healthy infants enrolled as controls in a tuberculosis vaccine study in Nyanza Province, Kenya provided anonymized samples for DNA sequence-based typing at the HLA-A, -B, -C, -DPB1, -DQA1, -DQB1, -DRB1, and -DRB3/4/5 loci. The purpose of the study was to characterize allele frequencies in the local population, to support studies of T cell immunity against pathogens, including Mycobacterium tuberculosis. There are no detectable deviations from Hardy Weinberg proportions for the HLA-B, -C, -DRB1, -DPB1, -DQA1 and -DQB1 loci. A minor deviation was detected at the HLA-A locus due to an excess of HLA-A*02:02, 29:02, 30:02, and 68:02 homozygotes. The genotype data are available in the Allele Frequencies Net Database under identifier 3393.

Details

Title: Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 100 Luo infants from the Boro area of Nyanza Province, Kenya
Authors/Creators: C.S.L. Arlehamn (Author/Creator) - La Jolla Institute for Immunology
R. Copin (Author/Creator) - New York University
S. Leary (Author/Creator) - Murdoch University
S.J. Mack (Author/Creator)
E. Phillips (Author/Creator) - Murdoch University
S. Mallal (Author/Creator) - Murdoch University
A. Sette (Author/Creator) - La Jolla Institute for Immunology
G. Blatner (Author/Creator) - Aeras
H. Siefers (Author/Creator) - Aeras
J.D. Ernst (Author/Creator) - New York University
Publication Details: Human Immunology, Vol.78(4), pp.325-326
Publisher: Elsevier BV
Identifiers: 991005544403407891
Copyright: © 2017 Published by Elsevier Inc. on behalf of American Society for Histocompatibility and Immunogenetics.
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.6 Immunology; 1.6.607 MHC Diversity
Web Of Science research areas: Immunology
ESI research areas: Immunology