Serological grouping of Treponema hyodysenteriae

D.J. Hampson; J.R.L. Mhoma; B.G. Combs; J.I. Lee

doi:10.1017/S0950268800047671

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Serological grouping of Treponema hyodysenteriae

Journal article

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Peer reviewed

Serological grouping of Treponema hyodysenteriae

D.J. Hampson, J.R.L. Mhoma, B.G. Combs and J.I. Lee

Epidemiology and Infection, Vol.105(01), pp.79-85

1990

DOI: https://doi.org/10.1017/S0950268800047671

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Abstract

Two Australian isolates of Treponema hyodysenteriae which did not fit within the current serological grouping system for these bacteria wrere examined by agarose gel double immunodiffusion tests (AGDP). Isolate Vic1 was serologically unique, and we propose that it becomes the type organism for a new sixth serological group of T. hyodysenteriae (Group F). Isolate Q1 was unusual in that lipopolysaccharide (LPS) extracted from it reacted strongly in AGDP with serum raised against the type organism for serogroup D (A1), and also weakly with serum raised against the type organism for serogroup B (WA1). The nature of this cross-reactivity was examined by using cross-absorbed antisera in AGDP, and by SDS-polyacrylamide gel electrophoresis (SDS-PAGE) and Western blot analysis. The pattern of serological cross-reactivity between Q1, A1 and WA1 was complex and was not fully defined, but the isolate Q1 apparently shared low molecular weight ‘serogroup’ LPS antigens with A1, and shared higher molecular weight LPS antigens with WA1. On this basis Q1 was designated as belonging to serogroup D, although it was recommended that this be qualified as D (B) to indicate the presence of weak cross-reactivity with serogroup B. Such serological cross-reactivity may have significance in relation to the development of immunity to T. hyodysenteriae. Isolate Q1 may be a potentially useful organism for vaccine development because of its ability to induce a good serological response to LPS of treponemes from both serogroups D and B.

Details

Title: Serological grouping of Treponema hyodysenteriae
Authors/Creators: D.J. Hampson (Author/Creator) - Murdoch University
J.R.L. Mhoma (Author/Creator) - Murdoch University
B.G. Combs (Author/Creator) - Murdoch University
J.I. Lee (Author/Creator) - Murdoch University
Publication Details: Epidemiology and Infection, Vol.105(01), pp.79-85
Publisher: Cambridge University Press
Identifiers: 991005542077007891
Murdoch Affiliation: School of Veterinary Studies
Language: English
Resource Type: Journal article

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Citation topics: 1 Clinical & Life Sciences; 1.248 Sexually Transmitted Infections; 1.248.2445 Lawsonia Intracellularis
Web Of Science research areas: Infectious Diseases; Public, Environmental & Occupational Health
ESI research areas: Social Sciences, general