Serum CCL20 and its association with SIRT1 activity in multiple sclerosis patients

R. Li; X. Sun; Y. Shu; Yuge Wang; Li Xiao; Z. Wang; X. Hu; A.G. Kermode; W. Qiu

doi:10.1016/j.jneuroim.2017.10.013

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Serum CCL20 and its association with SIRT1 activity in multiple sclerosis patients

Journal article

Open access

Peer reviewed

Serum CCL20 and its association with SIRT1 activity in multiple sclerosis patients

R. Li, X. Sun, Y. Shu, Yuge Wang, Li Xiao, Z. Wang, X. Hu, A.G. Kermode and W. Qiu

Journal of Neuroimmunology, Vol.313, pp.56-60

2017

DOI: https://doi.org/10.1016/j.jneuroim.2017.10.013

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Abstract

CCL20 is a potentially important component in the pathogenesis of multiple sclerosis (MS). SIRT1 exhibits a negative regulatory effect on a variety of inflammatory cytokines and can relieve experimental autoimmune encephalomyelitis. The association between the level of CCL20 and SIRT1 activity in MS patients has not been investigated. In the present study, blood samples were collected from 38 RRMS patients and 40 healthy controls. The serum CCL20 levels were measured by ELISA. SIRT1 activity was evaluated by fluorometric assay. We revealed elevated serum CCL20 concentrations in MS, and discovered an inverse correlation between CCL20 and SIRT1 activity in MS patients.

Details

Title: Serum CCL20 and its association with SIRT1 activity in multiple sclerosis patients
Authors/Creators: R. Li (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen University
X. Sun (Author/Creator)
Y. Shu (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen University
Yuge Wang (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen University
Li Xiao (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen University
Z. Wang (Author/Creator) - Guangdong 999 Brain Hospital
X. Hu (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen University
A.G. Kermode (Author/Creator) - Sir Charles Gairdner Hospital
W. Qiu (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen University
Publication Details: Journal of Neuroimmunology, Vol.313, pp.56-60
Publisher: Elsevier
Identifiers: 991005541672207891
Copyright: © 2017 Elsevier B.V.
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.264 Longevity; 1.264.1102 Resveratrol & Sirtuins
Web Of Science research areas: Immunology; Neurosciences
ESI research areas: Neuroscience & Behavior