Journal article
Serum NfL associated with anti-NMDA receptor encephalitis
Neurological Sciences
2022
Abstract
Introduction
Neurofilament light chains (NfL) have been reported as potential markers for neuronal-axonal injury in neuroinflammatory diseases. In the current study, we describe serum NfL levels as a prognostic marker for anti-N-methyl-D-aspartate receptor encephalitis (NMDARE).
Methods
Serum levels of NfL of 64 patients with anti-NMDARE and 84 healthy controls were measured by Simoa. The anti-NMDAR Encephalitis One-Year Functional Status (NEOS) score, Modified Rankin Scale (mRS) scores, and clinical and cerebrospinal fluid parameters were evaluated in patients with anti-NMDARE. Meanwhile, we performed a receiver-operator characteristic analysis to assess the power of the serum NFL in predicting the 1-year functional status.
Results
Serum NfL levels were significantly elevated in patients with anti-NMDARE compared to healthy controls (p < 0.001, padjusted < 0.001), especially in patients with severe impairments (mRS > 3 vs ≤ 3, p = 0.035) or with limited response to treatment (vs. favorable outcome, p = 0.011). Serum NFL was positively associated with the initial admission mRS (r = 0.23, p = 0.072) and 1-year mRS (r = 0.29, p = 0.018). The AUC of serum NfL and NEOS score for 1-year poor functional status was 0.697 (95% CI 0.527–0.866, p = 0.011), 0.753 (95% CI 0.616–0.890, p = 0.001), respectively. Furthermore, AUC of the combination of serum NfL and NEOS was 0.815 (95% CI 0.680–0.950, p < 0.001).
Conclusion
Our findings show that serum NfL levels evaluated in anti-NMDAR encephalitis may be a good predictor of the risk of 1-year poor functional status.
Details
- Title
- Serum NfL associated with anti-NMDA receptor encephalitis
- Authors/Creators
- X. Ma (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen UniversityY. Lu (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen UniversityF. Peng (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen UniversityY. Wang (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen UniversityX. Sun (Author/Creator)W. Luo (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen UniversityS. Shen (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen UniversityZ. Liu (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen UniversityA.G. Kermode (Author/Creator) - Murdoch UniversityW. Qiu (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen UniversityY. Shu (Author/Creator) - Third Affiliated Hospital of Sun Yat-sen University
- Publication Details
- Neurological Sciences
- Publisher
- Springer Nature
- Identifiers
- 991005542597907891
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.203 Neuromuscular Disorders
- 1.203.1602 Limbic Encephalitis
- Web Of Science research areas
- Clinical Neurology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior