Journal article
Serum high-density lipoprotein is associated with better cognitive function in a cross-sectional study of aging women
International Journal of Neuroscience, Vol.127(3), pp.243-252
2016
Abstract
Purpose/Aim of the study: Poor cardiovascular health, including obesity and altered lipid profiles at mid-life, are linked to increased risk of Alzheimer's disease (AD). The biological mechanisms linking cardiovascular health and cognitive function are unclear though are likely to be multifactorial. This study examined the association between various lipoproteins and cognitive functioning in ageing women. Materials and Methods: We investigated the relationship between readily available biomarkers (i.e. serum lipoprotein) and cognitive decline in domains associated with increased risk of AD (e.g. episodic verbal memory performance and subjective memory complaint). We report cross-sectional data investigating the relationship between serum total cholesterol, triglycerides, high-density lipoprotein (HDL-C) and low-density lipoprotein with verbal memory and learning ability in 130 women with and without memory complaints (n = 71 and 59, respectively) drawn from a study investigating cognitively healthy Western Australians (average age 62.5 years old). Results: After statistical modelling that controlled for the effects of age, depression and apolipoprotein E genotype, HDL-C was significantly associated with better verbal learning and memory performance, specifically short and long delay-free recalls (F = 3.062; p < .05 and F = 3.2670; p < .05, respectively). Conclusion: Our cross-sectional findings suggest that the positive effect of HDL-C on verbal memory may be present much earlier than previously reported and provide further support for the role of HDL-C in healthy brain ageing. Further exploration of the protective effect of HDL-C on cognitive function in ageing is warranted through follow-up, longitudinal studies.
Details
- Title
- Serum high-density lipoprotein is associated with better cognitive function in a cross-sectional study of aging women
- Authors/Creators
- K.A. Bates (Author/Creator) - The University of Western AustraliaH.R. Sohrabi (Author/Creator) - The University of Western AustraliaS.R. Rainey-Smith (Author/Creator)M. Weinborn (Author/Creator) - Edith Cowan UniversityR.S. Bucks (Author/Creator) - The University of Western AustraliaM. Rodrigues (Author/Creator) - Edith Cowan UniversityJ. Beilby (Author/Creator) - Pathwest Laboratory MedicineM. Howard (Author/Creator) - Edith Cowan UniversityK. Taddei (Author/Creator) - Edith Cowan UniversityG. Martins (Author/Creator) - Edith Cowan UniversityA. Paton (Author/Creator) - Edith Cowan UniversityT. Shah (Author/Creator) - Australian Alzheimer’s Research FoundationS.S. Dhaliwal (Author/Creator) - Curtin UniversityJ.K. Foster (Author/Creator) - Curtin UniversityI.J. Martins (Author/Creator) - Edith Cowan UniversityN.T. Lautenschlager (Author/Creator) - The University of Western AustraliaF.L. Mastaglia (Author/Creator) - Murdoch UniversityS.E. Gandy (Author/Creator) - Icahn School of Medicine at Mount SinaiR.N. Martins (Author/Creator) - The University of Western Australia
- Publication Details
- International Journal of Neuroscience, Vol.127(3), pp.243-252
- Publisher
- Taylor & Francis
- Identifiers
- 991005540917007891
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
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- Citation topics
- 1 Clinical & Life Sciences
- 1.52 Neurodegenerative Diseases
- 1.52.60 Dementia
- Web Of Science research areas
- Neurosciences
- ESI research areas
- Neuroscience & Behavior