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Journal article
Serum lipidomics reveals class-specific lipid remodelling and altered acyl chain composition in Parkinson's disease
Parkinsonism & related disorders, Vol.150, 108425
2026
PMID: 42447690
Abstract
Background: Lipid metabolism is increasingly implicated in Parkinson's Disease (PD) pathology, yet the specific lipid classes and acyl chain compositions involved, and their relationship with PD clinical symptoms, remain poorly characterised.
Objectives: We aimed to identify serum lipid signatures that differentiate people with PD (PwPD) from healthy controls and to evaluate associations with levodopa-induced dyskinesia (LID).
Methods: Serum collected from 58 PwPD and 58 age- and sex-matched non-PD controls was analysed using targeted liquid chromatography - mass spectrometry (LC-MS). Group differences were assessed using univariate and multivariate approaches. Logistic regression was used to identify lipids associated with LID among PwPD.
Results: Significantly lower levels of glycerolipids and glycerophospholipids were observed in PwPD compared to controls, alongside higher levels of lysophosphatidylethanolamines (LPE) and lysophosphatidylcholines (LPC). Analysis of individual lipid species revealed a lipid remodelling of the acyl chain composition of glycerolipids and glycerophospholipids, with decreased esterified arachidonic, adrenic, docosapentaenoic, and docosahexaenoic acids. Non-esterified arachidonic acid (p = 5.80e-6) and eicosapentaenoic acid (p = 3.65e-10) were elevated in PwPD. In secondary analyses, no lipids discriminated between PwPD with and without LID; however, these models were constrained by modest subgroup sizes and clinical heterogeneity between groups, limiting conclusions regarding lipid-based discrimination of LID status.
Conclusions: These findings demonstrate disease-associated remodelling of acyl chain composition across multiple lipid classes in PD, particularly selective depletion of esterified polyunsaturated fatty acids from glycerolipids and glycerophospholipids. Replication in independent cohorts is warranted to establish whether these pathways represent viable therapeutic targets.
Details
- Title
- Serum lipidomics reveals class-specific lipid remodelling and altered acyl chain composition in Parkinson's disease
- Authors/Creators
- Jack Price - Perron Institute for Neurological and Translational ScienceMari Muldmaa - North Estonia Medical CentreKatrin Sikk - North Estonia Medical CentrePille Taba - Tartu University HospitalLuke Whiley - Murdoch University, Centre for Computational and Systems MedicineSulev Kõks - Murdoch University, Personalised Medicine Centre
- Publication Details
- Parkinsonism & related disorders, Vol.150, 108425
- Publisher
- Elsevier Ltd.
- Number of pages
- 7
- Grant note
- Eesti Teadusagentuur (501100002301) Dementia Australia (501100009293)
- Identifiers
- 991005904174107891
- Copyright
- © 2026 The Authors.
- Murdoch Affiliation
- Personalised Medicine Centre; Centre for Computational and Systems Medicine
- Language
- English
- Resource Type
- Journal article
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