Serum metabolic profile predicts adverse central haemodynamics in patients with type 2 diabetes mellitus

S.B. Nikolic; L.M. Edwards; Y.V. Karpievitch; R. Wilson; J. Horne; M.J. Adams; J.E. Sharman

doi:10.1007/s00592-015-0802-4

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Journal article

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Serum metabolic profile predicts adverse central haemodynamics in patients with type 2 diabetes mellitus

S.B. Nikolic, L.M. Edwards, Y.V. Karpievitch, R. Wilson, J. Horne, M.J. Adams and J.E. Sharman

Acta Diabetologica, Vol.53(3), pp.367-375

2016

DOI: https://doi.org/10.1007/s00592-015-0802-4

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Abstract

Aims People with type 2 diabetes mellitus (T2DM) have abnormal peripheral and central haemodynamics at rest and during exercise, probably due to metabolic perturbations, but mechanisms are unknown. We used untargeted metabolomics to determine the relationships between metabolic perturbations and haemodynamics (peripheral and central) measured at rest and during exercise. Methods Serum samples from 39 participants with T2DM (62 ± 9 years; 46 % male) and 39 controls (52 ± 10 years; 51 % male) were analysed by liquid chromatography–mass spectrometry, nuclear magnetic resonance spectroscopy and principal component analysis. Scores on principal components (PC) were used to assess relationships with haemodynamics including peripheral and central BP, central augmentation index (AIx) and central augmentation pressure (AP). Results Participants with T2DM had higher resting and exercise haemodynamics (peripheral and central BP, central AIx and central AP) compared to controls (p < 0.05). PC that comprised of a signature metabolic pattern of T2DM was independently associated with resting and exercise central AIx and central AP (p < 0.05). Conclusions Serum metabolic profile was associated with central, but not peripheral, haemodynamics in T2DM participants, suggesting that metabolic irregularities may explain abnormal central haemodynamics in T2DM patients.

Details

Title: Serum metabolic profile predicts adverse central haemodynamics in patients with type 2 diabetes mellitus
Authors/Creators: S.B. Nikolic (Author/Creator) - Menzies Research Institute
L.M. Edwards (Author/Creator) - King's College London
Y.V. Karpievitch (Author/Creator) - University of Tasmania
R. Wilson (Author/Creator)
J. Horne (Author/Creator) - Central Science Laboratory
M.J. Adams (Author/Creator) - University of Tasmania
J.E. Sharman (Author/Creator) - Menzies Research Institute
Publication Details: Acta Diabetologica, Vol.53(3), pp.367-375
Publisher: Springer Milan
Identifiers: 991005540207507891
Copyright: © Springer-Verlag Italia 2015
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Industry collaboration; Domestic collaboration; International collaboration
Citation topics: 2 Chemistry; 2.211 Mass Spectrometry; 2.211.990 Metabolomics
Web Of Science research areas: Endocrinology & Metabolism
ESI research areas: Biology & Biochemistry