Journal article
Serum testosterone levels correlate with haemoglobin in middle-aged and older men
Internal Medicine Journal, Vol.39(8), pp.532-538
2009
Abstract
Background: Lower testosterone levels are associated with anaemia in older men and women. The relation between testosterone and haemoglobin (Hb) in younger and middle-aged men is less well defined. The aim of the study was to examine the association between testosterone and Hb levels in men spanning middle to older ages.
Methods: A cross-sectional analysis of 492 men aged 30.7–94.5 years from the Busselton Health Survey, Western Australia, was carried out. Haemoglobin (Hb), early-morning serum total testosterone and sex hormone-binding globulin (SHBG) were measured. Free testosterone was calculated using mass action equations.
Results: Haemoglobin correlated to total and free testosterone concentrations (r= 0.13, P= 0.003 and r= 0.20, P < 0.001, respectively). Hb and SHBG were inversely correlated (r=−0.14, P= 0.001). Hb increased across lowest to highest quartiles of total testosterone (P= 0.02) and free testosterone (P < 0.001), but not SHBG. After adjusting for age, waist circumference, smoking status, alcohol consumption, renal function and ferritin, total testosterone was associated with Hb (β= 0.037, P= 0.003) as was free testosterone (β= 2.32, P < 0.001), whereas SHBG was not associated.
Conclusion: Testosterone concentration modulates Hb levels in community-dwelling men across a wide age range. Further studies are needed to clarify implications of this association between testosterone and Hb in men.
Details
- Title
- Serum testosterone levels correlate with haemoglobin in middle-aged and older men
- Authors/Creators
- B.B. Yeap (Author/Creator) - The University of Western AustraliaJ. Beilin (Author/Creator) - Royal Perth HospitalZ. Shi (Author/Creator) - University of Newcastle AustraliaM.W. Knuiman (Author/Creator) - The University of Western AustraliaJ.K. Olynyk (Author/Creator) - Fremantle HospitalD.G. Bruce (Author/Creator) - The University of Western AustraliaE.A. Milward (Author/Creator) - Hunter Medical Research Institute
- Publication Details
- Internal Medicine Journal, Vol.39(8), pp.532-538
- Publisher
- Blackwell Publishing
- Identifiers
- 991005541560507891
- Copyright
- © 2009 The Authors
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.141 Hormone Therapy
- 1.141.1092 Testosterone and Steroids
- Web Of Science research areas
- Endocrinology & Metabolism
- ESI research areas
- Clinical Medicine