Serum thymidine kinase 1 and C-reactive protein as biomarkers for screening clinically healthy dogs for occult disease

K.A. Selting; C.R. Sharp; R. Ringold; J. Knouse

doi:10.1111/vco.12052

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Serum thymidine kinase 1 and C-reactive protein as biomarkers for screening clinically healthy dogs for occult disease

Journal article

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Peer reviewed

Serum thymidine kinase 1 and C-reactive protein as biomarkers for screening clinically healthy dogs for occult disease

K.A. Selting, C.R. Sharp, R. Ringold and J. Knouse

Veterinary and Comparative Oncology, Vol.13(4), pp.373-384

2013

DOI: https://doi.org/10.1111/vco.12052

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Abstract

Thymidine kinase (TK1) is a biomarker that correlates well with diagnosis and prognosis in certain canine cancers. Canine C‐reactive protein (cCRP) is a widely accepted marker of inflammation correlated with increased risk and severity of various diseases. We evaluated serum TK1 and cCRP concentrations in apparently healthy dogs (n = 360). All dogs were followed up for a minimum of 6 months by health questionnaire. All dogs with cancer were identified using a proprietary dual‐biomarker algorithm [termed Neoplasia Index (NI)]. Specificity of positive NI is 0.91 and high positive is 0.98. All‐cause mortality was 20% in dogs with elevated cCRP and 3% in dogs with low cCRP. The performance of serum TK1 and cCRP as tools for screening for occult cancer is improved when evaluated together. Serum TK1 and cCRP (unified in the NI) are useful in the screening of occult canine cancer. cCRP is useful in screening for other serious diseases.

Details

Title: Serum thymidine kinase 1 and C-reactive protein as biomarkers for screening clinically healthy dogs for occult disease
Authors/Creators: K.A. Selting (Author/Creator) - Veterinary Medical Teaching Hospital
C.R. Sharp (Author/Creator) - Tufts University
R. Ringold (Author/Creator) - Veterinary Diagnostics Institute
J. Knouse (Author/Creator) - Veterinary Medical Teaching Hospital
Publication Details: Veterinary and Comparative Oncology, Vol.13(4), pp.373-384
Publisher: John Wiley & Sons Ltd
Identifiers: 991005542792007891
Copyright: © 2013 The Authors
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.189 Genome Studies; 1.189.1853 Human Genetic Diversity
Web Of Science research areas: Veterinary Sciences
ESI research areas: Plant & Animal Science