Severity of mastitis symptoms as a predictor of C-reactive protein in milk and blood during lactation

C.M. Fetherston; J.I. Wells; P.E. Hartmann

doi:10.1089/bfm.2006.1.127

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Severity of mastitis symptoms as a predictor of C-reactive protein in milk and blood during lactation

Journal article

Open access

Peer reviewed

Severity of mastitis symptoms as a predictor of C-reactive protein in milk and blood during lactation

C.M. Fetherston, J.I. Wells and P.E. Hartmann

Breastfeeding Medicine, Vol.1(3), pp.127-135

2006

DOI: https://doi.org/10.1089/bfm.2006.1.127

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Abstract

OBJECTIVE: To investigate the presence of C-reactive protein (CRP) in breast milk and any relationship between changes in CRP in breast milk and blood, and the severity of systemic and breast symptoms experienced during mastitis. METHODS: Mothers (n = 26) were followed prospectively from day 5 postpartum to the end of their lactation. Milk from each breast, blood, 24-hour urine samples and data on breast and systemic pathologies were collected at reference intervals during the first 3 months postpartum, daily during the occurrence of any breast inflammation and at 7 days after resolution of symptoms. RESULTS: CRP in blood was significantly increased during mastitis (p < 0.001, df:1,81; F = 31) and severity of systemic symptoms was a significant predictor for changes of CRP in blood (p < 0.01; df:3,42; F = 9.6). During mastitis both the symptomatic breast (p < 0.001; df:1,79; F = 19) and the contralateral asymptomatic breast (p < 0.004; df:1,75; F = 8.7) had a significantly higher milk CRP when compared with women with no mastitis. CONCLUSIONS: Although an increasing severity of breast and systemic symptoms in mastitis was predictive of an increasing CRP in milk and blood, respectively, the presence of CRP in similar concentrations in the mastitis and asymptomatic breast suggests it is of little use in making a differential diagnosis between infective verses noninfective forms of mastitis.

Details

Title: Severity of mastitis symptoms as a predictor of C-reactive protein in milk and blood during lactation
Authors/Creators: C.M. Fetherston (Author/Creator)
J.I. Wells (Author/Creator)
P.E. Hartmann (Author/Creator)
Publication Details: Breastfeeding Medicine, Vol.1(3), pp.127-135
Publisher: Mary Ann Liebert Inc.
Identifiers: 991005543532907891
Copyright: © Mary Ann Liebert, Inc.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Citation topics: 1 Clinical & Life Sciences; 1.72 Obstetrics & Gynecology; 1.72.891 Breastfeeding
Web Of Science research areas: Obstetrics & Gynecology; Pediatrics
ESI research areas: Clinical Medicine