Abstract
To determine the effect of physical activity comparing 1 h continuous exercise vs. intermittent exercise combined with frequent meal consumption on glucose excursions and insulin secretion in healthy, obese individuals. Eleven healthy, obese subjects (>30 kg/m2) underwent three 12 h study days including sedentary behavior (SED), exercise ((EX) 1 h morning exercise, 60-65% VO2 max), and physical activity ((PA) 12 hourly, intensity-matched 5-minute bouts), where each subject completed all three conditions. No significant differences in baseline glucose, insulin or c-peptide concentrations across study conditions were observed (P>0.05). Glucose AUC for 12 h and 2 h were significantly different across study days, with AUC attenuated with PA compared to the EX condition (P<0.05). The 12 h incremental insulin AUC was reduced by PA compared to SED behavior(173,985+ or -3556.8 v. 227,352+ or -4581.2 pmol/L*min for 12h, respectively; P<0.05).