Journal article
Short-term changes in frequencies of circulating leukocytes associated with narrowband UVB phototherapy in people with clinically isolated syndrome
Scientific Reports, Vol.9(1)
2019
Abstract
Clinically isolated syndrome (CIS) is the earliest clinical episode in multiple sclerosis (MS). Low environmental exposure to UV radiation is implicated in risk of developing MS, and therefore, narrowband UVB phototherapy might delay progression to MS in people with CIS. Twenty individuals with CIS were recruited, and half were randomised to receive 24 sessions of narrowband UVB phototherapy over a period of 8 weeks. Here, the effects of narrowband UVB phototherapy on the frequencies of circulating immune cells and immunoglobulin levels after phototherapy are reported. Peripheral blood samples for all participants were collected at baseline, and 1, 2, 3, 6 and 12 months after enrolment. An extensive panel of leukocyte populations, including subsets of T cells, B cells, monocytes, dendritic cells, and natural killer cells were examined in phototherapy-treated and control participants, and immunoglobulin levels measured in serum. There were significant short-term increases in the frequency of naïve B cells, intermediate monocytes, and fraction III FoxP3+ T regulatory cells, and decreases in switched memory B cells and classical monocytes in phototherapy-treated individuals. Since B cells are increasingly targeted by MS therapies, the effects of narrowband UVB phototherapy in people with MS should be investigated further.
Details
- Title
- Short-term changes in frequencies of circulating leukocytes associated with narrowband UVB phototherapy in people with clinically isolated syndrome
- Authors/Creators
- S. Trend (Author/Creator) - The Kids Research Institute AustraliaA.P. Jones (Author/Creator) - The Kids Research Institute AustraliaL. Cha (Author/Creator) - The Kids Research Institute AustraliaM.N. Cooper (Author/Creator)S. Geldenhuys (Author/Creator) - The Kids Research Institute AustraliaM.J. Fabis-Pedrini (Author/Creator) - Perron Institute for Neurological and Translational ScienceW.M. Carroll (Author/Creator) - Perron Institute for Neurological and Translational ScienceJ.M. Cole (Author/Creator) - St John of God Health CareD.R. Booth (Author/Creator) - The University of SydneyR.M. Lucas (Author/Creator) - The University of Western AustraliaM.A. French (Author/Creator) - The University of Western AustraliaS.N. Byrne (Author/Creator) - The University of SydneyA.G. Kermode (Author/Creator) - Perron Institute for Neurological and Translational ScienceP.H. Hart (Author/Creator) - The Kids Research Institute Australia
- Publication Details
- Scientific Reports, Vol.9(1)
- Publisher
- Nature Publishing Group
- Identifiers
- 991005541552707891
- Copyright
- © 2019 Springer Nature Publishing AG
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.203 Neuromuscular Disorders
- 1.203.147 Multiple Sclerosis
- Web Of Science research areas
- Immunology
- ESI research areas
- Immunology