Journal article
Sigma factor modulation for cyanobacterial metabolic engineering
Trends in Microbiology, Vol.29(3), pp.266-277
2021
Abstract
Sigma (σ) factors are key regulatory proteins that control the transcription initiation in prokaryotes. In response to environmental or developmental cues, σ factors initiate the transcription of necessary genes responsible for maintaining a life-sustaining metabolic balance. Due to the significant role of σ factors in bacterial metabolism, their rational engineering for commercial metabolite production in photoautotrophic, cyanobacterial cells is a desirable venture. As cyanobacterial genomes typically encode multiple σ factors, effective execution of metabolic engineering efforts largely relies on uncovering the complicated gene regulatory network and further characterization of the members of σ factor regulatory circuits. This review outlines the prospects of σ factor in metabolic engineering of cyanobacteria, summarizes the challenges in the path towards an efficient strain construction and highlights the genomic context of putative regulators of cyanobacterial σ factors.
Details
- Title
- Sigma factor modulation for cyanobacterial metabolic engineering
- Authors/Creators
- A. Srivastava (Author/Creator)R.K. Varshney (Author/Creator)P. Shukla (Author/Creator)
- Publication Details
- Trends in Microbiology, Vol.29(3), pp.266-277
- Publisher
- Cell Press
- Identifiers
- 991005543092807891
- Copyright
- © 2020 Elsevier Ltd.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 3 Agriculture, Environment & Ecology
- 3.171 Photoproductivity
- 3.171.477 Microalgae Biotechnology
- Web Of Science research areas
- Biochemistry & Molecular Biology
- Microbiology
- ESI research areas
- Microbiology