Journal article
Single-cell analysis shows that adipose tissue of persons with both HIV and diabetes is enriched for clonal, cytotoxic, and CMV-specific CD4+ T cells
Cell Reports Medicine, Vol.2(2), Art. 100205
2021
Abstract
Persons with HIV are at increased risk for diabetes mellitus compared with individuals without HIV. Adipose tissue is an important regulator of glucose and lipid metabolism, and adipose tissue T cells modulate local inflammatory responses and, by extension, adipocyte function. Persons with HIV and diabetes have a high proportion of CX3CR1+ GPR56+ CD57+ (C-G-C+) CD4+ T cells in adipose tissue, a subset of which are cytomegalovirus specific, whereas individuals with diabetes but without HIV have predominantly CD69+ CD4+ T cells. Adipose tissue CD69+ and C-G-C+ CD4+ T cell subsets demonstrate higher receptor clonality compared with the same cells in blood, potentially reflecting antigen-driven expansion, but C-G-C+ CD4+ T cells have a more inflammatory and cytotoxic RNA transcriptome. Future studies will explore whether viral antigens have a role in recruitment and proliferation of pro-inflammatory C-G-C+ CD4+ T cells in adipose tissue of persons with HIV.
Details
- Title
- Single-cell analysis shows that adipose tissue of persons with both HIV and diabetes is enriched for clonal, cytotoxic, and CMV-specific CD4+ T cells
- Authors/Creators
- C.N. Wanjalla (Author/Creator) - Vanderbilt University Medical CenterW.J. McDonnell (Author/Creator) - Vanderbilt University Medical CenterR. Ram (Author/Creator) - Murdoch UniversityA. Chopra (Author/Creator) - Murdoch UniversityR. Gangula (Author/Creator) - Vanderbilt University Medical CenterS. Leary (Author/Creator) - Murdoch UniversityM. Mashayekhi (Author/Creator) - Vanderbilt University Medical CenterJ.D. Simmons (Author/Creator) - Vanderbilt University Medical CenterC.M. Warren (Author/Creator) - Vanderbilt University Medical CenterS. Bailin (Author/Creator) - Vanderbilt University Medical CenterC.L. Gabriel (Author/Creator) - Vanderbilt UniversityL. Guo (Author/Creator) - CVPath InstituteB.D. Furch (Author/Creator) - Vanderbilt University Medical CenterM.C. Lima (Author/Creator) - Vanderbilt University Medical CenterB.O. Woodward (Author/Creator) - Vanderbilt University Medical CenterL. Hannah (Author/Creator) - Vanderbilt University Medical CenterM.A. Pilkinton (Author/Creator) - Vanderbilt University Medical CenterD.T. Fuller (Author/Creator) - CVPath InstituteK. Kawai (Author/Creator) - CVPath InstituteR. Virmani (Author/Creator) - CVPath InstituteA.V. Finn (Author/Creator) - CVPath InstituteA.H. Hasty (Author/Creator) - Vanderbilt UniversityS.A. Mallal (Author/Creator) - Vanderbilt University Medical CenterS.A. Kalams (Author/Creator) - Vanderbilt University Medical CenterJ.R. Koethe (Author/Creator) - Vanderbilt University Medical Center
- Publication Details
- Cell Reports Medicine, Vol.2(2), Art. 100205
- Publisher
- Elsevier
- Identifiers
- 991005543233507891
- Copyright
- © 2021 Elsevier B.V.
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.66 HIV
- 1.66.1372 HIV Comorbidities
- Web Of Science research areas
- Cell Biology
- Medicine, Research & Experimental
- ESI research areas
- Clinical Medicine