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Published (Version of Record)CC BY V4.0, Open Access
Journal article
Single-cell genomic analysis in plants
Genes, Vol.9(1), Article 50
2018
Abstract
Individual cells in an organism are variable, which strongly impacts cellular processes. Advances in sequencing technologies have enabled single-cell genomic analysis to become widespread, addressing shortcomings of analyses conducted on populations of bulk cells. While the field of single-cell plant genomics is in its infancy, there is great potential to gain insights into cell lineage and functional cell types to help understand complex cellular interactions in plants. In this review, we discuss current approaches for single-cell plant genomic analysis, with a focus on single-cell isolation, DNA amplification, next-generation sequencing, and bioinformatics analysis. We outline the technical challenges of analysing material from a single plant cell, and then examine applications of single-cell genomics and the integration of this approach with genome editing. Finally, we indicate future directions we expect in the rapidly developing field of plant single-cell genomic analysis.
Details
- Title
- Single-cell genomic analysis in plants
- Authors/Creators
- Y. Yuan (Author/Creator) - School of Biological SciencesH.T. Lee (Author/Creator) - The University of QueenslandH. Hu (Author/Creator) - School of Biological SciencesA. Scheben (Author/Creator) - School of Biological SciencesD. Edwards (Author/Creator) - School of Biological Sciences
- Publication Details
- Genes, Vol.9(1), Article 50
- Publisher
- MDPI
- Identifiers
- 991005541400307891
- Copyright
- © 2018 by the authors
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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