Single-cell multi-omic approaches define common molecular and cellular signals of dominant antigen-driven cells at the site of drug-induced Stevens Johnson Syndrome and Toxic Epidermal Necrolysis (SJS/TEN) tissue damage

A. Gibson; Y. Li; M. Thorne; R. Ram; A. Palubinsky; P. Choshi; M. Porter; J. Trubiano; P. Deshpande; A. Chopra; S. Leary; R. Gangula; K. White; M. Pilkington; K. Konvinse; C-W Wang; R-Y Pan; S-I Hung; W-H Chung; J. Peter; S. Mallal; E. Phillips

doi:10.1016/j.jaci.2021.12.598

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Single-cell multi-omic approaches define common molecular and cellular signals of dominant antigen-driven cells at the site of drug-induced Stevens Johnson Syndrome and Toxic Epidermal Necrolysis (SJS/TEN) tissue damage

Journal article

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Single-cell multi-omic approaches define common molecular and cellular signals of dominant antigen-driven cells at the site of drug-induced Stevens Johnson Syndrome and Toxic Epidermal Necrolysis (SJS/TEN) tissue damage

A. Gibson, Y. Li, M. Thorne, R. Ram, A. Palubinsky, P. Choshi, M. Porter, J. Trubiano, P. Deshpande, A. Chopra, …

Journal of Allergy and Clinical Immunology, Vol.149(2), Art. AB181

2022

DOI: https://doi.org/10.1016/j.jaci.2021.12.598

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Abstract

Human leukocyte antigen (HLA)-restricted CD8+ T-cells expressing dominant T-cell receptor (TCR) clonotypes are recently implicated drivers of keratinocyte cell death, cutaneous blistering, and mortality in drug-induced Stevens Johnson Syndrome/Toxic epidermal necrolysis (SJS/TEN). Signatures of these effector population(s) remain undefined in affected tissue but hold utility for early diagnosis and targeted therapy.

Details

Title: Single-cell multi-omic approaches define common molecular and cellular signals of dominant antigen-driven cells at the site of drug-induced Stevens Johnson Syndrome and Toxic Epidermal Necrolysis (SJS/TEN) tissue damage
Authors/Creators: A. Gibson (Author/Creator)
Y. Li (Author/Creator)
M. Thorne (Author/Creator)
R. Ram (Author/Creator)
A. Palubinsky (Author/Creator)
P. Choshi (Author/Creator)
M. Porter (Author/Creator)
J. Trubiano (Author/Creator)
P. Deshpande (Author/Creator)
A. Chopra (Author/Creator)
S. Leary (Author/Creator)
R. Gangula (Author/Creator)
K. White (Author/Creator)
M. Pilkington (Author/Creator)
K. Konvinse (Author/Creator)
C-W Wang (Author/Creator)
R-Y Pan (Author/Creator)
S-I Hung (Author/Creator)
W-H Chung (Author/Creator)
J. Peter (Author/Creator)
S. Mallal (Author/Creator)
E. Phillips (Author/Creator)
Publication Details: Journal of Allergy and Clinical Immunology, Vol.149(2), Art. AB181
Publisher: Mosby Inc.
Identifiers: 991005544788607891
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
Language: English
Resource Type: Journal article

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