Single cell transcriptomics reveal polyclonal memory T cell responses in abacavir patch test positive skin

A.J. Redwood; F. Rwandamuriye; A. Chopra; S. Leary; R. Ram; W. McDonnell; K. Konvinse; K. White; R. Pavlos; D.M. Koelle; S. Mallal; E. Phillips

doi:10.1016/j.jaci.2019.09.013

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Single cell transcriptomics reveal polyclonal memory T cell responses in abacavir patch test positive skin

Journal article

Open access

Peer reviewed

Single cell transcriptomics reveal polyclonal memory T cell responses in abacavir patch test positive skin

A.J. Redwood, F. Rwandamuriye, A. Chopra, S. Leary, R. Ram, W. McDonnell, K. Konvinse, K. White, R. Pavlos, D.M. Koelle, …

Journal of Allergy and Clinical Immunology, Vol.144(5), pp.1413-1416.e7

2019

DOI: https://doi.org/10.1016/j.jaci.2019.09.013

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Abstract

Capsule Summary. Single-cell responses in HLA-B*57:01 abacavir patch test positive skin remote to the acute hypersensitivity reaction demonstrate polyclonal T-cell activation and proliferation characterized by a transcriptional and cellular response consistent with memory responses to altered peptides.

Details

Title: Single cell transcriptomics reveal polyclonal memory T cell responses in abacavir patch test positive skin
Authors/Creators: A.J. Redwood (Author/Creator) - Murdoch University
F. Rwandamuriye (Author/Creator) - Murdoch University
A. Chopra (Author/Creator) - Murdoch University
S. Leary (Author/Creator) - Murdoch University
R. Ram (Author/Creator) - Murdoch University
W. McDonnell (Author/Creator) - Vanderbilt University Medical Center
K. Konvinse (Author/Creator) - Vanderbilt University Medical Center
K. White (Author/Creator) - Vanderbilt University Medical Center
R. Pavlos (Author/Creator) - Murdoch University
D.M. Koelle (Author/Creator) - Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
S. Mallal (Author/Creator) - Vanderbilt University Medical Center
E. Phillips (Author/Creator) - Murdoch University
Publication Details: Journal of Allergy and Clinical Immunology, Vol.144(5), pp.1413-1416.e7
Publisher: Mosby Inc.
Identifiers: 991005545298007891
Copyright: © 2019 Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.265 Dermatology - Skin Allergies; 1.265.1140 Drug Hypersensitivity
Web Of Science research areas: Allergy; Immunology
ESI research areas: Immunology