Single leg cycle training is superior to double leg cycling in improving the oxidative potential and metabolic profile of trained skeletal muscle

C.R. Abbiss; L.G. Karagounis; P.B. Laursen; J.J. Peiffer; D.T. Martin; J.A. Hawley; N.N. Fatehee; J.C. Martin

doi:10.1152/japplphysiol.01247.2010

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Single leg cycle training is superior to double leg cycling in improving the oxidative potential and metabolic profile of trained skeletal muscle

C.R. Abbiss, L.G. Karagounis, P.B. Laursen, J.J. Peiffer, D.T. Martin, J.A. Hawley, N.N. Fatehee and J.C. Martin

Journal of Applied Physiology, Vol.110(5), pp.1248-1255

2011

DOI: https://doi.org/10.1152/japplphysiol.01247.2010

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Abstract

Single-leg cycling may enhance the peripheral adaptations of skeletal muscle to a greater extent than double-leg cycling. The purpose of the current study was to determine the influence of 3 wk of high-intensity single- and double-leg cycle training on markers of oxidative potential and muscle metabolism and exercise performance. In a crossover design, nine trained cyclists (78 +/- 7 kg body wt, 59 +/- 5 ml.kg(-1).min(-1) maximal O-2 consumption) performed an incremental cycling test and a 16-km cycling time trial before and after 3 wk of double-leg and counterweighted single-leg cycle training (2 training sessions per week). Training involved three (double) or six (single) maximal 4-min intervals with 6 min of recovery. Mean power output during the single-leg intervals was more than half that during the double-leg intervals (198 +/- 29 vs. 344 +/- 38 W, P < 0.05). Skeletal muscle biopsy samples from the vastus lateralis revealed a training-induced increase in Thr(172)-phosphorylated 5'-AMP-activated protein kinase alpha-subunit for both groups (P < 0.05). However, the increase in cytochrome c oxidase subunits II and IV and GLUT-4 protein concentration was greater following single-than double-leg cycling (P < 0.05). Training-induced improvements in maximal O-2 consumption (3.9 +/- 6.2% vs. 0.6 +/- 3.6%) and time-trial performance (1.3 +/- 0.5% vs. 2.3 +/- 4.2%) were similar following both interventions. We conclude that short-term high-intensity single-leg cycle training can elicit greater enhancement in the metabolic and oxidative potential of skeletal muscle than traditional double-leg cycling. Single-leg cycling may therefore provide a valuable training stimulus for trained and clinical populations.

Details

Title: Single leg cycle training is superior to double leg cycling in improving the oxidative potential and metabolic profile of trained skeletal muscle
Authors/Creators: C.R. Abbiss (Author/Creator) - Edith Cowan University
L.G. Karagounis (Author/Creator) - Melbourne Institute of Technology
P.B. Laursen (Author/Creator) - Edith Cowan University
J.J. Peiffer (Author/Creator) - Murdoch University
D.T. Martin (Author/Creator) - Australian Institute of Sport
J.A. Hawley (Author/Creator) - Melbourne Institute of Technology
N.N. Fatehee (Author/Creator) - Edith Cowan University
J.C. Martin (Author/Creator) - University of Utah
Publication Details: Journal of Applied Physiology, Vol.110(5), pp.1248-1255
Publisher: American Physiological Society
Identifiers: 991005544452407891
Murdoch Affiliation: School of Chiropractic and Sports Science
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.172 Sports Science; 1.172.648 Exercise Physiology
Web Of Science research areas: Physiology; Sport Sciences
ESI research areas: Biology & Biochemistry