Journal article
Site of autonomic deficit in Harlequin syndrome: local autonomic failure affecting the arm and the face
Annals of Neurology, Vol.34(6), pp.814-819
1993
Abstract
The site of autonomic deficit was investigated in 4 patients with loss of thermoregulatory flushing and sweating on one side of the face but no associated miosis (harlequin syndrome). In 2 patients the sudomotor deficit included the hand. Signs of postganglionic sympathetic deficit included pathological lacrimal sweating (2 patients) and supersensitivity to 1% phenylephrine eyedrops (3 patients). One or both pupils constricted excessively to 0.0625% pilocarpine eyedrops (3 patients), consistent with ocular parasympathetic deficit. These findings suggest that pre- or postganglionic cervical sympathetic fibers, and parasympathetic neurons in the ciliary ganglia, are compromised in harlequin syndrome. The finding of cholinergic supersensitivity in the iris muscles of patients with harlequin syndrome indicates a relationship with Holmes-Adie syndrome, Ross's syndrome, and the persistent autonomic deficit occasionally associated with Guillain-Barré syndrome.
Details
- Title
- Site of autonomic deficit in Harlequin syndrome: local autonomic failure affecting the arm and the face
- Authors/Creators
- P.D. Drummond (Author/Creator) - Murdoch UniversityJ.W. Lance (Author/Creator) - Prince of Wales Hospital
- Publication Details
- Annals of Neurology, Vol.34(6), pp.814-819
- Publisher
- Wiley
- Identifiers
- 991005543903907891
- Copyright
- © 1993 American Neurological Association
- Murdoch Affiliation
- School of Psychology
- Language
- English
- Resource Type
- Journal article
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