Size at birth and adult fat mass in twin sheep are determined in early gestation

S.N. Hancock; M.H. Oliver; C. McLean; A.L. Jaquiery; F.H. Bloomfield

doi:10.1113/jphysiol.2011.220699

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Size at birth and adult fat mass in twin sheep are determined in early gestation

Journal article

Peer reviewed

Size at birth and adult fat mass in twin sheep are determined in early gestation

S.N. Hancock, M.H. Oliver, C. McLean, A.L. Jaquiery and F.H. Bloomfield

The Journal of Physiology, Vol.590(5), pp.1273-1285

2012

DOI: https://doi.org/10.1113/jphysiol.2011.220699

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Abstract

- Reduced size at birth and shorter gestation length are both associated with increased risks of non‐communicable diseases (NCD) in later adult life. - Twins are born both smaller and earlier than singletons and adult twins also are reported to be at increased risk of common NCDs such as diabetes. - The smaller size and shorter gestation length of twins has been presumed to be due to a lack of intrauterine space and/or limitations of placental nutrient supply in late gestation, but there are few data to support this. - We show that size at birth and adult fat mass in twin sheep are determined largely in early gestation. - Knowledge of the mechanisms underlying early pregnancy determination of fetal growth and gestation length in twins are likely to increase understanding of how early pregnancy factors influence lifelong health for offspring from all pregnancies.

Details

Title: Size at birth and adult fat mass in twin sheep are determined in early gestation
Authors/Creators: S.N. Hancock (Author/Creator) - Gravida
M.H. Oliver (Author/Creator) - Gravida
C. McLean (Author/Creator) - Gravida
A.L. Jaquiery (Author/Creator) - Gravida
F.H. Bloomfield (Author/Creator) - Gravida
Publication Details: The Journal of Physiology, Vol.590(5), pp.1273-1285
Publisher: Wiley-Blackwell
Identifiers: 991005541280607891
Copyright: © 2012 The Authors. Journal of Physiology © 2012 The Physiological Society
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Citation topics: 1 Clinical & Life Sciences; 1.72 Obstetrics & Gynecology; 1.72.182 Maternal-Fetal Health
Web Of Science research areas: Neurosciences; Physiology
ESI research areas: Biology & Biochemistry