Sjögren syndrome with associated lymphocytic interstitial pneumonia successfully treated With tacrolimus and abatacept as an alternative to rituximab

G. Thompson; A. McLean-Tooke; J. Wrobel; M. Lavender; M. Lucas

doi:10.1016/j.chest.2017.12.010

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Sjögren syndrome with associated lymphocytic interstitial pneumonia successfully treated With tacrolimus and abatacept as an alternative to rituximab

Journal article

Peer reviewed

Sjögren syndrome with associated lymphocytic interstitial pneumonia successfully treated With tacrolimus and abatacept as an alternative to rituximab

G. Thompson, A. McLean-Tooke, J. Wrobel, M. Lavender and M. Lucas

Chest, Vol.153(3), pp.e41-e43

2018

DOI: https://doi.org/10.1016/j.chest.2017.12.010

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Abstract

Interstitial lung disease (ILD) is a significant complication of Sjögren syndrome (SS) associated with increased morbidity and mortality. The mainstay of treatment remains corticosteroid administration, with or without additional immunosuppressive therapies. Preliminary studies in SS have shown benefit in glandular and serologic parameters following treatment with the CTLA4 immunoglobulin fusion protein abatacept. Topical tacrolimus has been effective for ocular symptoms in SS, but systemic therapy has not been reported. We describe the first case, to our knowledge, of the successful use of a combination of systemic tacrolimus and abatacept in severe refractory SS and related ILD.

Details

Title: Sjögren syndrome with associated lymphocytic interstitial pneumonia successfully treated With tacrolimus and abatacept as an alternative to rituximab
Authors/Creators: G. Thompson (Author/Creator) - Sir Charles Gairdner Hospital
A. McLean-Tooke (Author/Creator) - Sir Charles Gairdner Hospital
J. Wrobel (Author/Creator) - Fiona Stanley Hospital
M. Lavender (Author/Creator) - Fiona Stanley Hospital
M. Lucas (Author/Creator) - Sir Charles Gairdner Hospital
Publication Details: Chest, Vol.153(3), pp.e41-e43
Publisher: Elsevier
Identifiers: 991005545049807891
Copyright: © 2017 American College of Chest Physicians.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.106 Rheumatology; 1.106.1420 Sjogren's Syndrome
Web Of Science research areas: Critical Care Medicine; Respiratory System
ESI research areas: Clinical Medicine