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Sleep, Sirtuin 1 and Alzheimer’s disease: A review
Journal article   Open access   Peer reviewed

Sleep, Sirtuin 1 and Alzheimer’s disease: A review

Mehrane Mehramiz, Tenielle Porter, Simon M. Laws and Stephanie R. Rainey-Smith
Aging brain, Vol.2, Art. 100050
2022
DOI: https://doi.org/10.1016/j.nbas.2022.100050
PMID: 36908890
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Published530.15 kBDownloadView
CC BY-NC-ND V4.0,  Open Access

Abstract

Alzheimer’s disease Aβ-amyloid Circadian clock Dementia Homeostasis Neurotransmitter SIRT1 Sirtuin 1 Sleep Tau
Sleep plays a major role in brain health, and cognition. Disrupted sleep is a well-described symptom of Alzheimer’s disease (AD). However, accumulating evidence suggests suboptimal sleep also increases AD risk. The deacetylase Sirtuin 1 (Sirt 1), encoded by the SIRT1 gene, impacts sleep via its relationship to wake-sleep neurotransmitters and somnogens. Evidence from animal and human studies supports a significant and complex relationship between sleep, Sirt 1/ SIRT1 and AD. Numerous hypotheses attempt to explain the critical impact of Sirt 1/ SIRT1 on wake- and sleep- promoting neurons, their related mechanisms and neurotransmitters. However, there is a paucity of studies assessing the interaction between sleep and Sirt 1/ SIRT1, as a principal component of sleep regulation, on AD pathology. In this review, we explore the potential association between Sirt 1/ SIRT1, sleep, and AD aetiology. Given sleep is a likely modifiable risk factor for AD, and recent studies suggest Sirt 1/ SIRT1 activation can be modulated by lifestyle or dietary approaches, further research in this area is required to explore its potential as a target for AD prevention and treatment.

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