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CC BY-NC V4.0, Open Access
Journal article
Sleep discrepancy and brain glucose metabolism in community-dwelling older adults
Aging brain, Vol.6, 100130
2024
Abstract
Sleep discrepancy (negative discrepancy reflects worse self-reported sleep than objective measures, such as actigraphy, and positive discrepancy the opposite) has been linked to adverse health outcomes. This study is first to investigate the relationship between sleep discrepancy and brain glucose metabolism (assessed globally and regionally via positron emission tomography), and to evaluate the contribution of insomnia severity and depressive symptoms to any associations. Using data from cognitively unimpaired community-dwelling older adults (N = 68), cluster analysis was used to characterise sleep discrepancy (for total sleep time (TST), wake after sleep onset (WASO), and sleep efficiency (SE)), and logistic regression was used to explore sleep discrepancy’s associations with brain glucose metabolism, while controlling for insomnia severity and depressive symptoms. Lower glucose metabolism across multiple brain regions was associated with negative discrepancy for WASO and SE, and positive discrepancy for WASO only (large effect sizes; β ≥ 0.5). Higher glucose metabolism in the superior parietal and posterior cingulate regions was associated with negative discrepancy for TST (large effect sizes; β ≥ 0.5). These associations remained when controlling for insomnia severity and depressive symptoms, suggesting a unique role of sleep discrepancy as a potential early behavioural marker of brain health.
Details
- Title
- Sleep discrepancy and brain glucose metabolism in community-dwelling older adults
- Authors/Creators
- Nadia Soh - The University of Western AustraliaMichael Weinborn - The University of Western AustraliaJames D. Doecke - CSIRO Health and BiosecurityRodrigo Canovas - Australian e-Health Research CentreVincent Doré - Australian e-Health Research CentreYing Xia - Australian e-Health Research CentreJurgen Fripp - CSIRO Health and BiosecurityKevin Taddei - Edith Cowan University (Australia, Perth)Romola S. Bucks - The University of Western AustraliaHamid R. Sohrabi - Murdoch University, Centre for Healthy AgeingRalph N. Martins - School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, AustraliaMelissa Ree - The University of Western AustraliaStephanie R. Rainey-Smith - Murdoch University, Centre for Healthy Ageing
- Publication Details
- Aging brain, Vol.6, 100130
- Publisher
- Elsevier Inc.
- Identifiers
- 991005718968707891
- Copyright
- © 2024 The Author(s).
- Murdoch Affiliation
- Centre for Healthy Ageing
- Language
- English
- Resource Type
- Journal article
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