Journal article
Soluble glycoprotein VI is raised in the plasma of patients with acute ischemic stroke
Stroke, Vol.42(2), pp.498-500
2011
Abstract
Background and Purpose- Ischemic stroke induced by thrombosis may be triggered by atherosclerotic plaque rupture and collagen-induced platelet activation. Collagen induces glycoprotein VI shedding. Methods- We measured plasma-soluble glycoprotein VI (sGPVI) by enzyme-linked immunosorbent assay in 159 patients with acute (<7-day) ischemic stroke and age/sex-matched community-based control subjects. Results- sGPVI was elevated in stroke compared with controls (P=0.0168). ORs were higher in Quartile 4 for stroke cases (P=0.0121), and sGPVI was significantly elevated in stroke associated with large artery disease across Quartiles 2 to 4 and small artery disease in Quartile 4. sGPVI decreased 3 to 6 months after antiplatelet treatment, consistent with elevated sGPVI due to platelet activation during the thrombotic event. sGPVI correlated with P-selectin (P=0.0007) and was higher in individuals with the GPVIa haplotype (P=0.024). CONCLUSION-: Glycoprotein VI shedding is implicated in the pathology of acute ischemic stroke.
Details
- Title
- Soluble glycoprotein VI is raised in the plasma of patients with acute ischemic stroke
- Authors/Creators
- M. Al-Tamimi (Author/Creator)E.E. Gardiner (Author/Creator)J.Y. Thom (Author/Creator)Y. Shen (Author/Creator)M.N. Cooper (Author/Creator)G.J. Hankey (Author/Creator)M.C. Berndt (Author/Creator)R.I. Baker (Author/Creator)R.K. Andrews (Author/Creator)
- Publication Details
- Stroke, Vol.42(2), pp.498-500
- Publisher
- American Heart Association
- Identifiers
- 991005544604907891
- Copyright
- © 2011 American Heart Association, Inc.
- Murdoch Affiliation
- Centre for Haemophilia and Thrombosis Research
- Language
- English
- Resource Type
- Journal article
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