Files and links (1)
CC BY V4.0, Open Access
Journal article
Source‐specific nitrate intake and incident dementia in the Danish Diet, Cancer and Health Study
Alzheimer's & dementia, Vol.21(12), e70995
2025
Abstract
INTRODUCTION
Dietary nitrate, through conversion to nitric oxide, which supports vascular and nervous system function, may lower dementia risk but may also form neurodegenerative N‐nitrosamines, depending on the nitrate source.
METHODS
We investigated associations between source‐specific nitrate and nitrite intake and incident and early‐onset dementia (<65 years) in 54,804 dementia‐free participants from the Danish Diet, Cancer and Health Cohort Study over ∼27 years. Nitrate and nitrite intakes were derived from food frequency questionnaires and nitrate and nitrite databases.
RESULTS
Higher plant‐sourced nitrate intake was non‐linearly associated with lower rates of incident dementia (fifth vs first quintile hazard ratio 95% confidence interval: 0.90 [0.83, 0.98]), while increased risk was seen for higher intakes of animal‐sourced, additive‐permitted meat‐sourced, and tap water‐sourced nitrate. Similar associations were seen for source‐specific nitrite intake and were more pronounced for early‐onset dementia. No clear effect modification was observed.
DISCUSSION
These findings highlight the importance of nitrate source in dementia risk and warrant further investigation. Highlights Plant nitrate is associated with a lower risk of incident and early‐onset dementia. Animal and tap water nitrate are associated with an increased risk of dementia. Encouraging consumption of plant‐based nitrate sources may lower risk of dementia.
Details
- Title
- Source‐specific nitrate intake and incident dementia in the Danish Diet, Cancer and Health Study
- Authors/Creators
- Catherine P Bondonno - Edith Cowan UniversityPratik Pokharel - Edith Cowan UniversityDorit Wielandt Erichsen - Danish Cancer SocietyLiezhou Zhong - Edith Cowan UniversityJörg Schullehner - Geological Survey of Denmark and GreenlandCecilie Kyrø - Danish Cancer SocietyKirsten Frederiksen - Danish Cancer SocietyPeter Fjeldstad Hendriksen - Danish Cancer SocietyFrederik Dalgaard - Gentofte HospitalLauren C Blekkenhorst - Royal Perth HospitalStephanie R Rainey-Smith - Murdoch UniversitySamantha L Gardener - Edith Cowan UniversityTorben Sigsgaard - Aarhus UniversityOle Raaschou-Nielsen - Danish Cancer SocietyAnne Tjønneland - University of CopenhagenJonathan M Hodgson - Edith Cowan UniversityChristina C Dahm - Aarhus UniversityAnja Olsen - Danish Cancer SocietyNicola P Bondonno - Danish Cancer Society
- Publication Details
- Alzheimer's & dementia, Vol.21(12), e70995
- Publisher
- Wiley Periodicals LLC on behalf of Alzheimer's Association.
- Number of pages
- 15
- Identifiers
- 991005840057607891
- Copyright
- © 2025 The Author(s).
- Murdoch Affiliation
- Centre for Healthy Ageing
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Metrics
4 Record Views