Spatial differences in the sites of direct and indirect activation of corticospinal neurones by magnetic stimulation

S.A. Wilson; B.L. Day; G.W. Thickbroom; F.L. Mastaglia

doi:10.1016/0924-980X(96)95148-6

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Spatial differences in the sites of direct and indirect activation of corticospinal neurones by magnetic stimulation

Journal article

Peer reviewed

Spatial differences in the sites of direct and indirect activation of corticospinal neurones by magnetic stimulation

S.A. Wilson, B.L. Day, G.W. Thickbroom and F.L. Mastaglia

Electroencephalography and Clinical Neurophysiology/Electromyography and Motor Control, Vol.101(3), pp.255-261

1996

DOI: https://doi.org/10.1016/0924-980X(96)95148-6

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Abstract

Transcranial magnetic stimulation (TMS) over the human motor cortex evokes multiple descending volleys possibly through activation of different elements within the brain. We have investigated whether such elements can be distinguished spatially. Using a figure of eight coil, TMS was delivered over multiple scalp sites during a low level voluntary contraction of the left first dorsal interosseous muscle. At near-threshold intensity, early or late surface electromyograph (EMG) components (relative to anodal response latency) could be preferentially evoked with the coil aligned in a medio-lateral (ML), antero-posterior (AP), or postero-anterior (PA) orientation. The optimal location of the earliest component with ML coil orientation was 8 mm medial and 5 mm anterior compared to a later component with AP orientation. The optimal location for the same latency EMG component mapped using two different coil orientations (AP and ML) was not significantly different. The optimal location of two different late components, one obtained with AP and the other with PA coil orientations, was similar. It is argued that the earliest TMS-evoked component results from direct activation of corticospinal cell axons while later components result from activation of these cells trans-synaptically (indirectly), and that consequently there is a substantial spatial separation between these activation sites.

Details

Title: Spatial differences in the sites of direct and indirect activation of corticospinal neurones by magnetic stimulation
Authors/Creators: S.A. Wilson (Author/Creator) - Queen Elizabeth II Medical Centre
B.L. Day (Author/Creator) - The University of Western Australia
G.W. Thickbroom (Author/Creator) - Queen Elizabeth II Medical Centre
F.L. Mastaglia (Author/Creator) - Queen Elizabeth II Medical Centre
Publication Details: Electroencephalography and Clinical Neurophysiology/Electromyography and Motor Control, Vol.101(3), pp.255-261
Publisher: Elsevier
Identifiers: 991005544195807891
Copyright: 1996 Elsevier Science Ireland Ltd
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.82 Gait & Posture; 1.82.811 Transcranial Magnetic Stimulation
Web Of Science research areas: Engineering, Biomedical; Neurosciences
ESI research areas: Neuroscience & Behavior