Species-specificity of a murine immunocontraceptive utilising murine cytomegalovirus as a gene delivery vector

L.M. Smith; M.L. Lloyd; N.L. Harvey; A.J. Redwood; M.A. Lawson; G.R. Shellam

doi:10.1016/j.vaccine.2004.12.009

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Species-specificity of a murine immunocontraceptive utilising murine cytomegalovirus as a gene delivery vector

Journal article

Peer reviewed

Species-specificity of a murine immunocontraceptive utilising murine cytomegalovirus as a gene delivery vector

L.M. Smith, M.L. Lloyd, N.L. Harvey, A.J. Redwood, M.A. Lawson and G.R. Shellam

Vaccine, Vol.23(23), pp.2959-2969

2005

DOI: https://doi.org/10.1016/j.vaccine.2004.12.009

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Abstract

Cytomegaloviruses are species-specific DNA viruses. Recombinant murine cytomegaloviruse (MCMV) expressing the mouse egg-coat protein zona pellucida 3 (mZP3) has been shown to sterilise female mice by breaking self-tolerance and inducing an immune response against the host ZP3. This virus has the potential to be used for mouse population control, however the effect of this recombinant immunocontraceptive virus in non-host species must be determined. Recombinant MCMV-mZP3, based on both laboratory and wild strains of virus, induced long-lived antibody responses against structural viral proteins and mZP3 when inoculated into laboratory rats, although no viral DNA or replicating virus was identified. The anti-mZP3 antibodies were specific for mouse ZP3, did not cross-react with rat ZP3, and had no effect on the fertility of the rats.

Details

Title: Species-specificity of a murine immunocontraceptive utilising murine cytomegalovirus as a gene delivery vector
Authors/Creators: L.M. Smith (Author/Creator) - The University of Western Australia
M.L. Lloyd (Author/Creator) - The University of Western Australia
N.L. Harvey (Author/Creator) - School of Molecular Sciences
A.J. Redwood (Author/Creator) - School of Pathology and Laboratory Medicine
M.A. Lawson (Author/Creator) - Animal Care Services
G.R. Shellam (Author/Creator) - The University of Western Australia
Publication Details: Vaccine, Vol.23(23), pp.2959-2969
Publisher: Elsevier BV
Identifiers: 991005544633307891
Copyright: © 2004 Elsevier Ltd.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.161 Virology - Identification & Sequencing; 1.161.711 Cytomegalovirus Infections
Web Of Science research areas: Immunology; Medicine, Research & Experimental
ESI research areas: Immunology