Spinal degeneration is associated with lumbar multifidus morphology in secondary care patients with low back or leg pain

J.R. Cooley; T.S. Jensen; P. Kjaer; A. Jacques; J. Théroux; J.J. Hebert

doi:10.1038/s41598-022-18984-1

Back

Journal article

Open access

Peer reviewed

Spinal degeneration is associated with lumbar multifidus morphology in secondary care patients with low back or leg pain

J.R. Cooley, T.S. Jensen, P. Kjaer, A. Jacques, J. Théroux and J.J. Hebert

Scientific Reports, Vol.12(1), Art. 14676

2022

DOI: https://doi.org/10.1038/s41598-022-18984-1

Files and links (2)

pdf

multifidus morphology.pdfDownload View

Published (Version of Record) Open Access

url

Free to Read *No subscription requiredView

Abstract

Associations between multifidus muscle morphology and degenerative pathologies have been implied in patients with non-specific low back pain, but it is unknown how these are influenced by pathology severity, number, or distribution. MRI measures of pure multifidus muscle cross-sectional area (CSA) were acquired from 522 patients presenting with low back and/or leg symptoms in an outpatient clinic. We explored cross-sectional associations between the presence, distribution, and/or severity of lumbar degenerative pathologies (individually and in aggregate) and muscle outcomes in multivariable analyses (beta coefficients [95% CI]). We identified associations between lower pure multifidus muscle CSA and disc degeneration (at two or more levels): − 4.51 [− 6.72; − 2.3], Modic 2 changes: − 4.06 [− 6.09; − 2.04], endplate defects: − 2.74 [− 4.58; − 0.91], facet arthrosis: − 4.02 [− 6.26; − 1.78], disc herniations: − 3.66 [− 5.8; − 1.52], and when > 5 pathologies were present: − 6.77 [− 9.76; − 3.77], with the last supporting a potential dose–response relationship between number of spinal pathologies and multifidus morphology. Our findings could hypothetically indicate that these spinal and muscle findings: (1) are part of the same degenerative process, (2) result from prior injury or other common antecedent events, or (3) have a directional relationship. Future longitudinal studies are needed to further examine the complex nature of these relationships.

Details

Title: Spinal degeneration is associated with lumbar multifidus morphology in secondary care patients with low back or leg pain
Authors/Creators: J.R. Cooley (Author/Creator) - Murdoch University
T.S. Jensen (Author/Creator) - Regionshospitalet Silkeborg
P. Kjaer (Author/Creator) - University of Southern Denmark
A. Jacques (Author/Creator) - The University of Notre Dame Australia
J. Théroux (Author/Creator) - Murdoch University
J.J. Hebert (Author/Creator) - Murdoch University
Publication Details: Scientific Reports, Vol.12(1), Art. 14676
Publisher: Springer Nature
Identifiers: 991005543141607891
Copyright: © 2022 The Authors.
Murdoch Affiliation: College of Science, Health, Engineering and Education
Language: English
Resource Type: Journal article

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Metrics

65 File views/ downloads

36 Record Views

12 Times Cited - Web of Science

See more details

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.129 Back pain; 1.129.98 Low Back Pain
Web Of Science research areas: Orthopedics
ESI research areas: Clinical Medicine