Spirochaetes as intestinal pathogens: Lessons from a Brachyspira genome

D.J. Hampson; N. Ahmed

doi:10.1186/1757-4749-1-10

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Spirochaetes as intestinal pathogens: Lessons from a Brachyspira genome

Journal article

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Spirochaetes as intestinal pathogens: Lessons from a Brachyspira genome

D.J. Hampson and N. Ahmed

Gut Pathogens, Vol.1(1)

2009

DOI: https://doi.org/10.1186/1757-4749-1-10

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Abstract

Anaerobic spirochaetes of the genus Brachyspira have long been known as important gut pathogens of pigs, but increasingly they are recognised as causing disease in birds and other animal species, including human beings. The genome sequence of the major swine pathogen Brachyspira hyodysenteriae was recently published, and this revealed extensive genome optimisation that leads to adaptation to the complex environment of the colon. The genome sequences of other pathogenic and non-pathogenic Brachyspira species are becoming available, and this data will help to reveal how these species have evolved and adapted to varied lifestyles in the large intestines of different species, and why some but not others can induce colitis and diarrhoea.

Details

Title: Spirochaetes as intestinal pathogens: Lessons from a Brachyspira genome
Authors/Creators: D.J. Hampson (Author/Creator) - Murdoch University
N. Ahmed (Author/Creator) - University of Hyderabad
Publication Details: Gut Pathogens, Vol.1(1)
Publisher: BioMed Central
Identifiers: 991005544819407891
Copyright: © 2009 Hampson and Ahmed
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Language: English
Resource Type: Journal article
Note: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.248 Sexually Transmitted Infections; 1.248.2445 Lawsonia Intracellularis
Web Of Science research areas: Gastroenterology & Hepatology; Microbiology
ESI research areas: Clinical Medicine