Journal article
Sporadic inclusion body myositis: HLA-DRB1 allele interactions influence disease risk and clinical phenotype
Neuromuscular Disorders, Vol.19(11), pp.763-765
2009
Abstract
Susceptibility to sIBM is strongly associated with the HLA-DRB1*03 allele and the 8.1 MHC ancestral haplotype (HLA-A1, B8, DRB1*03) but little is known about the effects of allelic interactions at the DRB1 locus or disease-modifying effects of HLA alleles. HLA-A, B and DRB1 genotyping was performed in 80 Australian sIBM cases and the frequencies of different alleles and allele combinations were compared with those in a group of 190 healthy controls. Genotype-phenotype correlations were also investigated. Amongst carriers of the HLA-DRB1*03 allele, DRB1*03/*01 heterozygotes were over-represented in the sIBM group (p < 0.003) while. DRB1*03/*04 heterozygotes were under-represented (p < 0.008). The mean age-at-onset (AAO) was 6.5 years earlier in DRB1*03/*01 heterozygotes who also had more severe quadriceps muscle weakness than the rest of the cohort. The findings indicate that interactions between the HLA-DRB1*03 allele and other alleles at the DRB1 locus can influence disease susceptibility and the clinical phenotype in sIBM.
Details
- Title
- Sporadic inclusion body myositis: HLA-DRB1 allele interactions influence disease risk and clinical phenotype
- Authors/Creators
- F.L. Mastaglia (Author/Creator)M. Needham (Author/Creator)A. Scott (Author/Creator)I. James (Author/Creator)P. Zilko (Author/Creator)T. Day (Author/Creator)L. Kiers (Author/Creator)A. Corbett (Author/Creator)C.S. Witt (Author/Creator)R. Allcock (Author/Creator)N. Laing (Author/Creator)M. Garlepp (Author/Creator)F.T. Christiansen (Author/Creator)
- Publication Details
- Neuromuscular Disorders, Vol.19(11), pp.763-765
- Publisher
- Elsevier BV
- Identifiers
- 991005545339607891
- Copyright
- © 2009 Elsevier B.V.
- Murdoch Affiliation
- Centre for Clinical Immunology and Biomedical Statistics
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.106 Rheumatology
- 1.106.1684 Dermatomyositis
- Web Of Science research areas
- Clinical Neurology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior