Journal article
Sporadic inclusion body myositis in Japanese is associated with the MHC ancestral haplotype 52.1
Neuromuscular Disorders, Vol.16(5), pp.311-315
2006
Abstract
In Caucasians, sporadic inclusion body myositis has been associated with the MHC ancestral haplotypes; HLA-A1, B8, DR3 (8.1AH) and HLA-B35, DR1 (35.2AH). It is not known whether these haplotypes carry susceptibility for the disease in other ethnic groups. We report here the results of HLA-B and -DRB1 typing using a high-resolution sequence-based technique in a cohort of 31 Japanese patients with definite sIBM. Patient allele frequencies were 40.3% for HLA-B*5201 (10.7% in controls: p<0.001) and 37.1% for HLA-DRB1*1502 (10% in controls: p<0.001). Both alleles were found together as part of a conserved haplotype (52.1AH) at a frequency of 37.1% in patients (8.4% in controls: p<0.001). This is the first description of a haplotypic MHC association with sporadic inclusion body myositis in Japanese patients. These findings indicate that different MHC ancestral haplotypes are associated with sIBM in different ethnic groups and further emphasize the importance of genetic factors in this condition.
Details
- Title
- Sporadic inclusion body myositis in Japanese is associated with the MHC ancestral haplotype 52.1
- Authors/Creators
- A.P. Scott (Author/Creator) - The University of Western AustraliaR.J.N. Allcock (Author/Creator) - The University of Western AustraliaF. Mastaglia (Author/Creator) - The University of Western AustraliaI. Nishino (Author/Creator) - National Center of Neurology and PsychiatryI. Nonaka (Author/Creator) - National Center of Neurology and PsychiatryN. Laing (Author/Creator) - The University of Western Australia
- Publication Details
- Neuromuscular Disorders, Vol.16(5), pp.311-315
- Publisher
- Elsevier BV
- Identifiers
- 991005541115907891
- Copyright
- © 2006 Elsevier B.V.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.106 Rheumatology
- 1.106.1684 Dermatomyositis
- Web Of Science research areas
- Clinical Neurology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior