Staphylococci in high resolution: Capturing diversity within the human nasal microbiota

Anna Cäcilia Ingham; Duncan Y.K. Ng; Søren Iversen; Cindy M. Liu; Khoa Manh Dinh; Silva Holtfreter; Sofie Marie Edslev; Thor Bech Johannesen; Amalie Katrine Rendboe; Mette Theilgaard Christiansen; Kim Lee Ng; Robert Skov; Stefanie Samietz; Dörte Radke; Stefan Weiss; Uwe Völker; Barbara M. Bröker; Lise Tornvig Erikstrup; Christian Erikstrup; Paal Skytt Andersen; Lance B. Price; Marc Stegger

doi:10.1016/j.celrep.2025.115854

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Staphylococci in high resolution: Capturing diversity within the human nasal microbiota

Journal article

Open access

Peer reviewed

Staphylococci in high resolution: Capturing diversity within the human nasal microbiota

Anna Cäcilia Ingham, Duncan Y.K. Ng, Søren Iversen, Cindy M. Liu, Khoa Manh Dinh, Silva Holtfreter, Sofie Marie Edslev, Thor Bech Johannesen, Amalie Katrine Rendboe, Mette Theilgaard Christiansen, …

Cell reports (Cambridge), Vol.44(6), 115854

2025

DOI: https://doi.org/10.1016/j.celrep.2025.115854

PMID: 40517386

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Abstract

antagonist

carriage

community state type

microbial abundance

microbiome

nasal microbiota

staphylococci

Staphylococcus aureus

Staphylococcus epidermidis

Staphylococci include both nasal commensals and opportunistic pathogens, globally responsible for a large proportion of infection-related deaths, especially in S. aureus carriers. To understand staphylococcal temporal dynamics within the nasal microbiota, we employed Staphylococcus-targeted sequencing in two cohorts from Denmark and Germany. We identified two major staphylococcal community state types (sCSTs)—one dominated by S. aureus and one dominated by S. epidermidis—and eight subgroups defined by co-colonizing coagulase-negative staphylococci. The distribution of sCSTs was similar between the two cohorts. Predominance of either S. aureus or S. epidermidis was highly persistent over time, whereas co-colonizing staphylococcal species were transient with varying stability among the sCST subgroups. Detection of S. aureus by culture was positively associated with absolute abundance by qPCR. S. aureus domination was diminished when Dolosigranulum and Corynebacterium co-occurred. Our findings could inform efforts to reduce S. aureus nasal colonization and infection. [Display omitted]

Details

Title: Staphylococci in high resolution: Capturing diversity within the human nasal microbiota
Authors/Creators: Anna Cäcilia Ingham - Statens Serum Institut
Duncan Y.K. Ng - Statens Serum Institut
Søren Iversen - Statens Serum Institut
Cindy M. Liu - Milken Institute
Khoa Manh Dinh - Copenhagen University Hospital
Silva Holtfreter - Universitätsmedizin Greifswald
Sofie Marie Edslev - Statens Serum Institut
Thor Bech Johannesen - Statens Serum Institut
Amalie Katrine Rendboe - Statens Serum Institut
Mette Theilgaard Christiansen - Statens Serum Institut
Kim Lee Ng - Statens Serum Institut
Robert Skov - Statens Serum Institut
Stefanie Samietz - Universitätsmedizin Greifswald
Dörte Radke - Universitätsmedizin Greifswald
Stefan Weiss - Universitätsmedizin Greifswald
Uwe Völker - Universitätsmedizin Greifswald
Barbara M. Bröker - Universitätsmedizin Greifswald
Lise Tornvig Erikstrup - Aarhus University Hospital
Christian Erikstrup - Aarhus University Hospital
Paal Skytt Andersen - Statens Serum Institut
Lance B. Price - Milken Institute
Marc Stegger - Statens Serum Institut
Publication Details: Cell reports (Cambridge), Vol.44(6), 115854
Publisher: Elsevier Inc.
Number of pages: 18
Identifiers: 991005788078207891
Murdoch Affiliation: Harry Butler Institute
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.23 Antibiotics & Antimicrobials; 1.23.173 MRSA and VRE
Web Of Science research areas: Cell Biology
ESI research areas: Molecular Biology & Genetics