Journal article
Staphylococcus aureus plasmids without mobilization genes are mobilized by a novel conjugative plasmid from community isolates
Journal of Antimicrobial Chemotherapy, Vol.70(3), pp.649-652
2015
Abstract
Objectives: To describe a family of conjugative plasmids isolated from colonizing community Staphylococcus aureus and determine their ability to mobilize unrelated antimicrobial resistance/virulence plasmids, not encoding mobilization functions. Methods: Plasmid pWBG749 was labelled with Tn551 (pWBG749e) to enable laboratory manipulation. Plasmid pWBG749e was conjugated into S. aureus of seven different lineages that harboured unrelated plasmids and mobilization experiments were performed. Plasmids were screened by EcoRI restriction and hybridization with probes prepared from unique pWBG749 conjugation genes. Results: Conjugative plasmids pWBG745, pWBG748 and pWBG749 belong to the same conjugative-plasmid family as the vancomycin resistance plasmid pBRZ01. Plasmid pWBG749e mobilized five unrelated plasmids. Mobilized plasmid pWBG744 is a pIB485-family plasmid that was also found in international S. aureus. Conclusions: Plasmid pWBG749e can mobilize unrelated S. aureus plasmids whose means of dissemination have not previously been understood.
Details
- Title
- Staphylococcus aureus plasmids without mobilization genes are mobilized by a novel conjugative plasmid from community isolates
- Authors/Creators
- F.G. O'Brien (Author/Creator)J.P. Ramsay (Author/Creator)S. Monecke (Author/Creator)G.W. Coombs (Author/Creator)O.J. Robinson (Author/Creator)Z. Htet (Author/Creator)F.A.M. Alshaikh (Author/Creator)W.B. Grubb (Author/Creator)
- Publication Details
- Journal of Antimicrobial Chemotherapy, Vol.70(3), pp.649-652
- Publisher
- Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy
- Identifiers
- 991005540665507891
- Copyright
- © The Author 2014.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
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- Citation topics
- 1 Clinical & Life Sciences
- 1.23 Antibiotics & Antimicrobials
- 1.23.173 MRSA and VRE
- Web Of Science research areas
- Infectious Diseases
- Microbiology
- Pharmacology & Pharmacy
- ESI research areas
- Pharmacology & Toxicology