Journal article
Stimulation of HIV-specific T cell clonotypes using allogeneic HLA
Cellular Immunology, Vol.316, pp.32-40
2017
Abstract
We hypothesized that HIV-specific CD8 T cell clonotypes can be stimulated by allogeneic HLA molecules. Multiple HIV-specific CD8 T cell clones were derived from 12 individuals with chronic HIV infection, specific for 13 different HIV Gag antigens and restricted to 7 different HLA molecules. The generated T cell clones were assayed for alloreactivity against a panel of single HLA class I expressing cell lines (SALs). HIV-specific T cells recognising at least one allogeneic HLA molecule could be identified from 7 of 12 patients tested. Allorecognition was associated with IFNγ cytokine production, CD137 upregulation and cytotoxicity, suggesting high avidity allo-stimulation. Allo-HLA recognition by HIV-specific T cells was specific to the HIV target peptide/HLA restriction and TCR TRBV usage of the T cells. HIV-specific T cells do crossreact against allogeneic HLA molecules in an epitope and TRBV specific manner. Therefore allo-HLA stimulation could be exploited to induce or augment HIV-specific T cell responses.
Details
- Title
- Stimulation of HIV-specific T cell clonotypes using allogeneic HLA
- Authors/Creators
- C. Almeida (Author/Creator)P. van Miert (Author/Creator)K. O'Driscoll (Author/Creator)Y.M. Zoet (Author/Creator)A. Chopra (Author/Creator)M. Watson (Author/Creator)D. de Santis (Author/Creator)C. Witt (Author/Creator)M. John (Author/Creator)F.H.J. Claas (Author/Creator)L.J. D'Orsogna (Author/Creator)
- Publication Details
- Cellular Immunology, Vol.316, pp.32-40
- Publisher
- Academic Press Inc.
- Identifiers
- 991005542687007891
- Copyright
- © 2017 Elsevier Inc.
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.66 HIV
- 1.66.46 HIV Pathogenesis
- Web Of Science research areas
- Cell Biology
- Immunology
- ESI research areas
- Immunology