Strategies for the Development of pH-Responsive Synthetic Polypeptides and Polymer-Peptide Hybrids: Recent Advancements

Cintya Dharmayanti; Todd A. Gillam; Manuela Klingler-Hoffmann; Hugo Albrecht; Anton Blencowe

doi:10.3390/polym13040624

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Strategies for the Development of pH-Responsive Synthetic Polypeptides and Polymer-Peptide Hybrids: Recent Advancements

Journal article

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Peer reviewed

Strategies for the Development of pH-Responsive Synthetic Polypeptides and Polymer-Peptide Hybrids: Recent Advancements

Cintya Dharmayanti, Todd A. Gillam, Manuela Klingler-Hoffmann, Hugo Albrecht and Anton Blencowe

Polymers, Vol.13(4), 624

2021

DOI: https://doi.org/10.3390/polym13040624

PMID: 33669548

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Abstract

Physical Sciences

Polymer Science

Science & Technology

Synthetic polypeptides and polymer-peptide hybrid materials have been successfully implemented in an array of biomedical applications owing to their biocompatibility, biodegradability and ability to mimic natural proteins. In addition, these materials have the capacity to form complex supramolecular structures, facilitate specific biological interactions, and incorporate a diverse selection of functional groups that can be used as the basis for further synthetic modification. Like conventional synthetic polymers, polypeptide-based materials can be designed to respond to external stimuli (e.g., light and temperature) or changes in the environmental conditions (e.g., redox reactions and pH). In particular, pH-responsive polypeptide-based systems represent an interesting avenue for the preparation of novel drug delivery systems that can exploit physiological or pathological pH variations within the body, such as those that arise in the extracellular tumour microenvironment, intracellularly within endosomes/lysosomes, or during tissue inflammation. Here, we review the significant progress made in advancing pH-responsive polypeptides and polymer-peptide hybrid materials during the last five years, with a particular emphasis on the manipulation of ionisable functional groups, pH-labile linkages, pH-sensitive changes to secondary structure, and supramolecular interactions.

Details

Title: Strategies for the Development of pH-Responsive Synthetic Polypeptides and Polymer-Peptide Hybrids: Recent Advancements
Authors/Creators: Cintya Dharmayanti - University of South Australia
Todd A. Gillam - University of South Australia
Manuela Klingler-Hoffmann - University of South Australia
Hugo Albrecht - University of South Australia
Anton Blencowe - University of South Australia
Publication Details: Polymers, Vol.13(4), 624
Publisher: MDPI
Number of pages: 16
Grant note: Australian Government
Identifiers: 991005845393307891
Murdoch Affiliation: School of Mathematics, Statistics, Chemistry and Physics
Language: English
Resource Type: Journal article

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Citation topics: 2 Chemistry; 2.53 Polymers & Macromolecules; 2.53.70 Nanocarrier Drug Delivery
Web Of Science research areas: Polymer Science
ESI research areas: Chemistry