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Streptomyces misionensis PESB-25 Produces a thermoacidophilic endoglucanase using sugarcane bagasse and corn steep liquor as the sole organic substrates
Journal article   Open access   Peer reviewed

Streptomyces misionensis PESB-25 Produces a thermoacidophilic endoglucanase using sugarcane bagasse and corn steep liquor as the sole organic substrates

Marcella Novaes Franco-Cirigliano, Raquel De Carvalho Rezende, Mônica Pires Gravina-Oliveira, Pedro Henrique Freitas Pereira, Rodrigo Pires Do Nascimento, Elba Pinto Da Silva Bon, Andrew Macrae and Rosalie Reed Rodrigues Coelho
BioMed research international, Vol.2013, 584207
2013
PMID: 23586048
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Published (Version of Record) Open Access CC BY V4.0

Abstract

Streptomyces misionensis strain PESB-25 was screened and selected for its ability to secrete cellulases. Cells were grown in a liquid medium containing sugarcane bagasse (SCB) as carbon source and corn steep liquor (CSL) as nitrogen source, whose concentrations were optimized using response surface methodology (RSM). A peak of endoglucanase accumulation (1.01 U·mL−1) was observed in a medium with SCB 1.0% (w/v) and CSL 1.2% (w/v) within three days of cultivation. S. misionensis PESB-25 endoglucanase activity was thermoacidophilic with optimum pH and temperature range of 3.0 to 3.6 and 62° to 70°C, respectively. In these conditions, values of 1.54 U mL−1 of endoglucanase activity were observed. Moreover, Mn2+ was demonstrated to have a hyperactivating effect on the enzyme. In the presence of MnSO4 (8 mM), the enzyme activity increased threefold, up to 4.34 U·mL−1. Mn2+ also improved endoglucanase stability as the catalyst retained almost full activity upon incubation at 50°C for 4 h, while in the absence of Mn2+, enzyme activity decreased by 50% in this same period. Three protein bands with endoglucanase activity and apparent molecular masses of 12, 48.5 and 119.5 kDa were detected by zymogram.

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