Journal article
Studies on failure of T strain live Babesia bovis vaccine
Australian Veterinary Journal, Vol.72(8), pp.296-300
1995
Abstract
Field investigations of the protection afforded by the Australian live Babesia bovis vaccine used in the early 1990s (T strain) revealed inadequate vaccine-induced protection in certain herds. Vaccination/challenge trials using 207 experimental cattle were conducted to evaluate the protection afforded by T strain B bovis against field isolates from these herds. The trials investigated whether isolates that could ‘break-through’ T strain immunity were present in the field, the ability or inability of specific cattle to develop protective immunity after vaccination with T strain and the effect of attenuation and maintenance procedures on the immunogenicity of T strain.
The results showed that B bovis parasites present early in the process of attenuation of T strain were more protective than those remaining late in the process. They also showed that cattle from properties experiencing vaccine failures were less protected by T strain vaccination than Bos taurus cattle randomly selected from the general population if vaccinated with highly attenuated T strain. A hypothesis is offered to explain these findings.
Details
- Title
- Studies on failure of T strain live Babesia bovis vaccine
- Authors/Creators
- R.E. Bock (Author/Creator) - *Tick Fever Research Centre, 280 Grindle Road, Wacol, Queensland 4076A.J. Vos (Author/Creator) - *Tick Fever Research Centre, 280 Grindle Road, Wacol, Queensland 4076A. Lew (Author/Creator) - Animal Research InstituteT.G. Kingston (Author/Creator) - *Tick Fever Research Centre, 280 Grindle Road, Wacol, Queensland 4076I.R. Fraser (Author/Creator) - Dagger;Queensland Department of Primary Industries, 123 Wharf Street, Maryborough, Queensland 4650
- Publication Details
- Australian Veterinary Journal, Vol.72(8), pp.296-300
- Publisher
- Wiley-Blackwell
- Identifiers
- 991005542942007891
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.258 Zoonotic Diseases
- 1.258.227 Tick-borne Pathogens
- Web Of Science research areas
- Veterinary Sciences
- ESI research areas
- Plant & Animal Science