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Study of The Placentae of Patients with Neuromyelitis Optica Spectrum Disorder
Journal article   Peer reviewed

Study of The Placentae of Patients with Neuromyelitis Optica Spectrum Disorder

Y.Y. Chang, Y.Q. Shu, X.B. Sun, T.T. Lu, C. Chen, L. Fang, D. He, C.F. Xu, Z.Q. Lu, H.Q. Hu, …
Multiple Sclerosis Journal, Vol.24(3)
2018
DOI: https://doi.org/10.1177/1352458517751792
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Abstract

Background: Previous studies have shown that circulating AQP4-IgG may lead to negative consequences during pregnancy in NMOSD patients. Objectives: To explore whether AQP4-IgG influences pregnancy by affecting AQP4 expression and inducing placental inflammation in patients with neuromyelitis optica spectrum disorder(NMOSD). Methods: We prospectively collected clinical data from six pregnant AQP4-IgG-seropositive NMOSD patients and their infants, and investigated AQP4 expression and placental inflammatory infiltration by comparing haematoxylin and eosin and immunohistochemical (AQP4, AQP1, C5b-9, IgG, CD3, CD8, CD20, and CD68) staining results with a healthy control. Results: Four patients were term pregnant, and their infants were normal for development; their serum AQP4-IgG was positive at birth, and three infants were negative for AQP4-IgG after 3 months. Two patients underwent induced abortion; one because of NMOSD relapse and another because of fetal malformation. Histological investigation showed normal structure of the chorionic villi, and no significant difference in the intensity of the immune histochemical staining for AQP1, AQP4, and inflammatory markers in placentae of patients and the control. Conclusions: There was no decrease in placental AQP4 expression, and no obvious placental inflammation or signs of damage in term placentae of NMOSD patients seropositive for AQP4-IgG.

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