Subjective memory decline predicts greater rates of clinical progression in preclinical Alzheimer's disease

R.F. Buckley; P. Maruff; D. Ames; P. Bourgeat; R.N. Martins; C.L. Masters; S. Rainey-Smith; N. Lautenschlager; C.C. Rowe; G. Savage; V.L. Villemagne; K.A. Ellis

doi:10.1016/j.jalz.2015.12.013

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Subjective memory decline predicts greater rates of clinical progression in preclinical Alzheimer's disease

Journal article

Peer reviewed

Subjective memory decline predicts greater rates of clinical progression in preclinical Alzheimer's disease

R.F. Buckley, P. Maruff, D. Ames, P. Bourgeat, R.N. Martins, C.L. Masters, S. Rainey-Smith, N. Lautenschlager, C.C. Rowe, G. Savage, …

Alzheimer's & Dementia, Vol.12(7), pp.796-804

2016

DOI: https://doi.org/10.1016/j.jalz.2015.12.013

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Abstract

Introduction: The objective of this study was to determine the utility of subjective memory decline (SMD) to predict episodic memory change and rates of clinical progression in cognitively normal older adults with evidence of high β-amyloid burden (CN Aβ+). Methods: Fifty-eight CN Aβ+ participants from the Australian Imaging, Biomarkers, and Lifestyle study responded to an SMD questionnaire and underwent comprehensive neuropsychological assessments. Participant data for three follow-up assessments were analyzed. Results: In CN Aβ+, subjects with high SMD did not exhibit significantly greater episodic memory decline than those with low SMD. High SMD was related to greater rates of progression to mild cognitive impairment or Alzheimer's disease (AD) dementia (hazard ratio = 5.1; 95% confidence interval, 1.4-20.0, P = .02) compared with low SMD. High SMD was associated with greater depressive symptomatology and smaller left hippocampal volume. Discussion: High SMD is a harbinger of greater rates of clinical progression in preclinical AD. Although SMD reflects broader diagnostic implications for CN Aβ+, more sensitive measures may be required to detect early subtle cognitive change.

Details

Title: Subjective memory decline predicts greater rates of clinical progression in preclinical Alzheimer's disease
Authors/Creators: R.F. Buckley (Author/Creator) - The University of Melbourne
P. Maruff (Author/Creator) - Cogstate Ltd, Melbourne, Australia
D. Ames (Author/Creator) - St Vincent's Health
P. Bourgeat (Author/Creator) - The Australian eHealth Research Centre, CSIRO Health & Biosecurity Flagship, QLD, Australia.
R.N. Martins (Author/Creator) - Edith Cowan University
C.L. Masters (Author/Creator) - Florey Institute of Neuroscience and Mental Health
S. Rainey-Smith (Author/Creator)
N. Lautenschlager (Author/Creator) - St Vincent's Health
C.C. Rowe (Author/Creator) - Austin Health
G. Savage (Author/Creator) - ARC Centre of Excellence in Cognition and its Disorders
V.L. Villemagne (Author/Creator) - Austin Health
K.A. Ellis (Author/Creator) - St Vincent's Health
Publication Details: Alzheimer's & Dementia, Vol.12(7), pp.796-804
Publisher: Elsevier Inc.
Identifiers: 991005543588307891
Copyright: © 2016 The Alzheimer's Association.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Industry collaboration; Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.52 Neurodegenerative Diseases; 1.52.60 Dementia
Web Of Science research areas: Clinical Neurology
ESI research areas: Neuroscience & Behavior