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Journal article
Suboptimal self‐reported sleep efficiency and duration are associated with faster accumulation of brain amyloid beta in cognitively unimpaired older adults
Alzheimer's & dementia : diagnosis, assessment & disease monitoring, Vol.16(2), e12579
2024
Appears in Open Access via Read & Publish Agreements
Abstract
INTRODUCTION: This study investigated whether self-reported sleep quality is associated with brain amyloid beta (Aβ) accumulation.
METHODS: Linear mixed effect model analyses were conducted for 189 cognitively unimpaired (CU) older adults (mean ± standard deviation 74.0 ± 6.2; 53.2% female), with baseline self-reported sleep data, and positron emission tomography-determined brain Aβ measured over a minimum of three time points (range 33.3–72.7 months). Analyses included random slopes and intercepts, interaction for apolipoprotein E (APOE) ε4 allele status, and time, adjusting for sex and baseline age.
RESULTS: Sleep duration <6 hours, in APOE ε4 carriers, and sleep efficiency <65%, in the whole sample and APOE ε4 non-carriers, is associated with faster accumulation of brain Aβ.
DISCUSSION: These findings suggest a role for self-reported suboptimal sleep efficiency and duration in the accumulation of Alzheimer's disease (AD) neuropathology in CU individuals. Additionally, poor sleep efficiency represents a potential route via which individuals at lower genetic risk may progress to preclinical AD.
Highlights
• In cognitively unimpaired older adults self-report sleep is associated with brain amyloid beta (Aβ) accumulation.
• Across sleep characteristics, this relationship differs by apolipoprotein E (APOE) genotype.
• Sleep duration <6 hours is associated with faster brain Aβ accumulation in APOE ε4 carriers.
• Sleep efficiency < 65% is associated with faster brain Aβ accumulation in APOE ε4 non-carriers.
• Personalized sleep interventions should be studied for potential to slow Aβ accumulation.
Details
- Title
- Suboptimal self‐reported sleep efficiency and duration are associated with faster accumulation of brain amyloid beta in cognitively unimpaired older adults
- Authors/Creators
- Louise N. Pivac - Murdoch UniversityBelinda M. Brown - Murdoch UniversityKelsey R. Sewell - Murdoch UniversityJames D. Doecke - Australian e-Health Research CentreVictor L. Villemagne - University of PittsburghVincent Doré - Australian e-Health Research CentreMichael Weinborn - The University of Western AustraliaHamid R. Sohrabi - Murdoch UniversitySamantha L. Gardener - Edith Cowan UniversityRomola S. Bucks - The University of Western AustraliaSimon M. Laws - Edith Cowan UniversityKevin Taddei - Edith Cowan University (Australia, Perth)Paul Maruff - Florey Institute of Neuroscience and Mental HealthColin L. Masters - The University of MelbourneChristopher Rowe - Austin HealthRalph N. Martins - Edith Cowan University (Australia, Perth)Stephanie R. Rainey-Smith - Centre for Healthy Ageing, Health Futures Institute Murdoch University Alzheimer's Research Australia, Sarich Neuroscience Research Institute University of Western Australia Edith Cowan University
- Publication Details
- Alzheimer's & dementia : diagnosis, assessment & disease monitoring, Vol.16(2), e12579
- Publisher
- Wiley Periodicals LLC on behalf of Alzheimer's Association
- Grant note
- Victorian Government's Operational Infrastructure Support program The Yulgilbar Foundation Alzheimer's Research Australia Sir Charles Gairdner Hospital Alzheimer's Association (US) National Health and Medical Research Council (NHMRC : GNT1197315) Hollywood Private Hospital St Vincent's Hospital Cogstate Ltd an anonymous foundation
- Identifiers
- 991005656645707891
- Copyright
- © 2024 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
- Murdoch Affiliation
- School of Psychology; Research and Innovation Office; Centre for Healthy Ageing
- Language
- English
- Resource Type
- Journal article
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